天然抗炎化合物作为阿尔茨海默病的候选药物

Title:Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease

Volume: 28 Issue: 23

关键词: 淀粉样前体蛋白黄酮类，阿尔茨海默病，BACE-1，小胶质细胞，天然产物，植物化学物质。

摘要: Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, and oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. Therefore, to develop new drugs with protective action against the disease, research is turning to the identification of plant products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Phytochemicals, including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol, were reported molecules for the treatment of AD. Several alkaloids, such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine and anatabine, have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.

Cite this article as:

Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease, Current Medicinal Chemistry 2021; 28 (23) . https://dx.doi.org/10.2174/0929867327666200730213215