Title:Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic and Immune Disorders
Volume: 21
Issue: 5
Author(s): Ciro Gargiulo Isacco, Andrea Ballini *, Danila De Vito, Kieu Cao Diem Nguyen, Stefania Cantore, Lucrezia Bottalico, Lucio Quagliuolo, Mariarosaria Boccellino, Marina Di Domenico, Luigi Santacroce, Roberto Arrigoni, Gianna Dipalma and Francesco Inchingolo
Affiliation:
- Department of Precision Medicine, University of Campania Luigi Vanvitelli , 80100 Naples, Italy
Keywords:
Periodontal disease, oral dysbiosis, gut dysbiosis, central nervous system (CNS) diseases, probiotics, macrophages.
Abstract: The current treatment and prevention procedures of oral disorders follow a very targeted
approach considering mouth and its structures as a system that is completely independent, than the rest
of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an
acceptable range compatible with oral-mouth health, completely separated from systemic microbial
homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic
disease and its progression. Dysbiosis occurs as a consequence of imbalance in oral and gut microbiota
which leads to cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Alzheimer’s
disease, as reported in current literature. Likewise, there is a need to highlight and develop a
novel philosophical approach in the treatments for oral diseases that will necessarily involve nonconventional
approaches.