Title:A Facile, Efficient Step-Wise and Alternative Synthesis of Indolyl Triazoles via “Click” Chemistry
Volume: 18
Issue: 11
Author(s): G. Ganga Reddy, B. Srinivasa Reddy and Ch. Venkata Ramana Reddy*
Affiliation:
- Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, College of Engineering, Kukatpally, Hyderabad, Telangana 500 085,India
Keywords:
Knoevengal condensation, 1, 2, 3 triazole, N-propargylation, click chemistry, aryl azides, step-wise and alternative
synthesis.
Abstract: series of new 1,2,3 triazoles hybrids were synthesized using a Cu-catalysed azide-alkyne
cycloaddition reaction. Thus, a remarkable rapid click reaction of aryl azides with terminal alkynes at
room temperature in DMF afforded new 4-((1-((1-(4-methoxy-3-nitrophenyl)-1H-1,2,3-triazol-4-
yl)methyl)-1H-indol-3-yl)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-ones in good to excellent
yields. The reaction provides a safe, efficient and economic approach for the synthesis of various 1,2,3
triazoles. The reaction has many advantages like shorter reaction times, good yields of products and
isolation of the products without the need for column chromatography. By using knoevenagel reaction
under physical grinding with alkylating agents prepared various 1,2,3 triazoles.