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Review Article

Physiological and Pharmacological Effects of Glucocorticoids on the Gastrointestinal Tract

Author(s): Ludmila Filaretova*, Tatiana Podvigina and Natalia Yarushkina

Volume 26, Issue 25, 2020

Page: [2962 - 2970] Pages: 9

DOI: 10.2174/1381612826666200521142746

Price: $65

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Abstract

The review considers the data on the physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focuses on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological gastroprotective effects of glucocorticoids to pathological proulcerogenic consequences. The results of experimental studies on the re-evaluation of the traditional notion that stress-produced glucocorticoids are ulcerogenic led us to the opposite conclusion suggested that these hormones play an important role in the maintenance of the gastric mucosal integrity. Exogenous glucocorticoids may exert both gastroprotective and proulcerogenic effects. Initially, gastroprotective effect of dexamethasone but not corticosterone, cortisol or prednisolone can be transformed into proulcerogenic one. The most significant factor for the transformation is the prolongation of its action rather the dose. Gastrointestinal injury can be accompanied by changes in somatic pain sensitivity and glucocorticoids contribute to these changes playing a physiological and pathological role.

Keywords: Stress, glucocorticoids, hypothalamic-pituitary-adrenocortical axis, gastric mucosa, erosion, ulcer, gastroprotective effect, ulcerogenic effect, somatic pain, mechanisms of transformation.

« Previous Next »
[1]
O’Malley P. Gastric ulcers and GERD: the new “plagues” of the 21st century update for the clinical nurse specialist. Clin Nurse Spec 2003; 17(6): 286-9.
[http://dx.doi.org/10.1097/00002800-200311000-00008] [PMID: 14986731]
[2]
Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 2008; 135(1): 41-60.
[http://dx.doi.org/10.1053/j.gastro.2008.05.030] [PMID: 18549814]
[3]
Graham DY. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol 2014; 20(18): 5191-204.
[http://dx.doi.org/10.3748/wjg.v20.i18.5191] [PMID: 24833849]
[4]
Farzaei MH, Abdollahi M, Rahimi R. Role of dietary polyphenols in the management of peptic ulcer. World J Gastroenterol 2015; 21(21): 6499-517.
[http://dx.doi.org/10.3748/wjg.v21.i21.6499] [PMID: 26074689]
[5]
Bardou M, Quenot JP, Barkun A. Stress-related mucosal disease in the critically ill patient. Nat Rev Gastroenterol Hepatol 2015; 12(2): 98-107.
[http://dx.doi.org/10.1038/nrgastro.2014.235] [PMID: 25560847]
[6]
Whitehouse MW. Anti-inflammatory glucocorticoid drugs: reflections after 60 years. Inflammopharmacology 2011; 19(1): 1-19.
[http://dx.doi.org/10.1007/s10787-010-0056-2] [PMID: 21072600]
[7]
Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn’t the stomach digest itself? Physiol Rev 2008; 88(4): 1547-65.
[http://dx.doi.org/10.1152/physrev.00004.2008] [PMID: 18923189]
[8]
Takeuchi K. Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility. World J Gastroenterol 2012; 18(18): 2147-60.
[http://dx.doi.org/10.3748/wjg.v18.i18.2147] [PMID: 22611307]
[9]
Luo J-C, Cho C-H, Ng K-M, et al. Dexamethasone inhibits tumor necrosis factor-alpha-stimulated gastric epithelial cell migration. J Chin Med Assoc 2009; 72(10): 509-14.
[http://dx.doi.org/10.1016/S1726-4901(09)70419-8] [PMID: 19837644]
[10]
Olsen M, Christensen S, Riis A, Thomsen RW. Preadmission use of systemic glucocorticoids and 30-day mortality following bleeding peptic ulcer: a population-based cohort study. Am J Ther 2010; 17(1): 23-9.
[http://dx.doi.org/10.1097/MJT.0b013e318197c57c] [PMID: 19531935]
[11]
Martínek J, Hlavova K, Zavada F, et al. “A surviving myth”--corticosteroids are still considered ulcerogenic by a majority of physicians. Scand J Gastroenterol 2010; 45(10): 1156-61.
[http://dx.doi.org/10.3109/00365521.2010.497935] [PMID: 20569095]
[12]
Tseng C-L, Chen Y-T, Huang C-J, et al. Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study. Aliment Pharmacol Ther 2015; 42(5): 599-606.
[http://dx.doi.org/10.1111/apt.13298] [PMID: 26096497]
[13]
Reinau D, Schwenkglenks M, Früh M, Signorell A, Blozik E, Meier CR. Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case-Control Analysis Based on Swiss Claims Data. Drug Saf 2018; 41(7): 725-30.
[http://dx.doi.org/10.1007/s40264-018-0645-3] [PMID: 29468603]
[14]
Narum S, Westergren T, Klemp M. Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis. BMJ Open 2014; 4(5)e004587
[http://dx.doi.org/10.1136/bmjopen-2013-004587] [PMID: 24833682]
[15]
Kondo Y, Hatta W, Koike T, et al. The Use of Higher Dose Steroids Increases the Risk of Rebleeding After Endoscopic Hemostasis for Peptic Ulcer Bleeding. Dig Dis Sci 2018; 63(11): 3033-40.
[http://dx.doi.org/10.1007/s10620-018-5209-y] [PMID: 30022453]
[16]
Black HE. The effects of steroids upon the gastrointestinal tract. Toxicol Pathol 1988; 16(2): 213-22.
[http://dx.doi.org/10.1177/019262338801600214] [PMID: 3055231]
[17]
Bandyopadhyay U, Biswas K, Bandyopadhyay D, Ganguly CK, Banerjee RK. Dexamethasone makes the gastric mucosa susceptible to ulceration by inhibiting prostaglandin synthetase and peroxidase-two important gastroprotective enzymes. Mol Cell Biochem 1999; 202(1-2): 31-6.
[http://dx.doi.org/10.1023/A:1007018212822] [PMID: 10705992]
[18]
Takeuchi Y, Takahashi M, Fuchikami J. Vulnerability of gastric mucosa to prednisolone in rats chronically exposed to cigarette smoke. J Pharmacol Sci 2008; 106(4): 585-92.
[http://dx.doi.org/10.1254/jphs.FP0071606] [PMID: 18385541]
[19]
Filep JG, Hermán F, Földes-Filep E, Schneider F, Braquet P. Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor. Br J Pharmacol 1992; 105(4): 912-8.
[http://dx.doi.org/10.1111/j.1476-5381.1992.tb09077.x] [PMID: 1324056]
[20]
Wallace JL. Glucocorticoid-induced gastric mucosal damage: inhibition of leukotriene, but not prostaglandin biosynthesis. Prostaglandins 1987; 34(2): 311-23.
[http://dx.doi.org/10.1016/0090-6980(87)90252-8] [PMID: 2823319]
[21]
Derelanko MJ, Long JF. Influence of prednisolone on ethanol-induced gastric injury in the rat. Dig Dis Sci 1982; 27(2): 149-54.
[http://dx.doi.org/10.1007/BF01311709] [PMID: 7075409]
[22]
McCafferty DM, Granger DN, Wallace JL. Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats. Gastroenterology 1995; 109(4): 1173-80.
[http://dx.doi.org/10.1016/0016-5085(95)90576-6] [PMID: 7557083]
[23]
Filaretova L, Podvigina T, Bagaeva T, Morozova O. Dual action of glucocorticoid hormones on the gastric mucosa: how the gastroprotective action can be transformed to the ulcerogenic one. Inflammopharmacology 2009; 17(1): 15-22.
[http://dx.doi.org/10.1007/s10787-008-8046-3] [PMID: 19139829]
[24]
Filaretova L, Morozova O, Bagaeva T, Podvigina T. From gastroprotective to proulcerogenic action of glucocorticoids on the gastric mucosa. J Physiol Pharmacol 2009; 60(Suppl. 7): 79-86.
[PMID: 20388949]
[25]
Filaretova L, Podvigina T, Bagaeva T, Morozova O. From gastroprotective to ulcerogenic effects of glucocorticoids: role of long-term glucocorticoid action. Curr Pharm Des 2014; 20(7): 1045-50.
[http://dx.doi.org/10.2174/13816128113199990419] [PMID: 23782149]
[26]
Takeuchi K, Nishiwaki H, Okada M, Niida H, Okabe S. Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility. Gastroenterology 1989; 97(2): 284-93.
[http://dx.doi.org/10.1016/0016-5085(89)90063-2] [PMID: 2744352]
[27]
Suzuki H, Miura S, Mori M, et al. Protective role of adrenal glucocorticoids for gastric mucosa in spontaneously hypertensive rats. J Gastroenterol Hepatol 1999; 14(4): 376-83.
[http://dx.doi.org/10.1046/j.1440-1746.1999.01861.x] [PMID: 10207789]
[28]
Szabo S, Gallagher GT, Horner HC, et al. Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls, and cimetidine in the rat. Gastroenterology 1983; 85(6): 1384-90.
[http://dx.doi.org/10.1016/S0016-5085(83)80022-5] [PMID: 6605275]
[29]
Perretti M, Mugridge KG, Wallace JL, Parente L. Reduction of aspirin-induced gastric damage in rats by interleukin-1 β: possible involvement of endogenous corticosteroids. J Pharmacol Exp Ther 1992; 261(3): 1238-47.
[PMID: 1602386]
[30]
Filaretova LP. [The dependence of the formation of stress stomach ulcers on the function of the hypothalamo-hypophyseal-adrenal cortical system]. Fiziol Zh SSSR Im I M Sechenova 1990; 76(11): 1594-600.
[PMID: 1964432]
[31]
Filaretova L. The hypothalamic-pituitary-adrenocortical system: Hormonal brain-gut interaction and gastroprotection. Auton Neurosci 2006; 125(1-2): 86-93.
[http://dx.doi.org/10.1016/j.autneu.2006.01.005] [PMID: 16481222]
[32]
Filaretova L. Glucocorticoids are gastroprotective under physiologic conditions. Ther Adv Chronic Dis 2011; 2(5): 333-42.
[http://dx.doi.org/10.1177/2040622311412420] [PMID: 23251759]
[33]
Filaretova LP, Filaretov AA, Makara GB. Corticosterone increase inhibits stress-induced gastric erosions in rats. Am J Physiol 1998; 274(6): G1024-30.
[PMID: 9696701]
[34]
Filaretova L, Bagaeva T, Podvigina T, Makara G. Various ulcerogenic stimuli are potentiated by glucocorticoid deficiency in rats. J Physiol Paris 2001; 95(1-6): 59-65.
[http://dx.doi.org/10.1016/S0928-4257(01)00069-9] [PMID: 11595419]
[35]
Filaretova LP, Bagaeva TR, Amagase K, Takeuchi K. Contribution of glucocorticoids to protective influence of preconditioning mild stress against stress-induced gastric erosions. Ann N Y Acad Sci 2008; 1148: 209-12.
[http://dx.doi.org/10.1196/annals.1410.005] [PMID: 19120111]
[36]
Filaretova L, Bagaeva T, Morozova O. Stress and the stomach: Corticotropin-releasing factor may protect the gastric mucosa in stress through involvement of glucocorticoids. Cell Mol Neurobiol 2012; 32(5): 829-36.
[http://dx.doi.org/10.1007/s10571-012-9800-z] [PMID: 22290156]
[37]
Filaretova L, Bagaeva T. The Realization of the Brain-Gut Interactions with Corticotropin-Releasing Factor and Glucocorticoids. Curr Neuropharmacol 2016; 14(8): 876-81.
[http://dx.doi.org/10.2174/1570159X14666160614094234] [PMID: 27306034]
[38]
Filaretova L, Myazina M, Bagaeva T. Stress-induced corticosterone rise maintain gastric mucosal integrity in rats. Ideggyogy Sz 2016; 69(9-10): 313-7.
[http://dx.doi.org/10.18071/isz.69.0313] [PMID: 29638095]
[39]
Filaretova L. Gastroprotective effect of stress preconditioning: involvement of glucocorticoids. Curr Pharm Des 2017; 23(27): 3923-7.
[http://dx.doi.org/10.2174/1381612823666170215145125] [PMID: 28215149]
[40]
Selye H In Vivo The case for supramolecular biology presented in six informal, illustrated lectures. New York: Liveright 1967.
[41]
Szabo S, Tache Y, Somogyi A. The legacy of Hans Selye and the origins of stress research: a retrospective 75 years after his landmark brief “letter” to the editor of nature. Stress 2012; 15(5): 472-8.
[http://dx.doi.org/10.3109/10253890.2012.710919] [PMID: 22845714]
[42]
Selye H. A syndrome produced by diverse nocuous agents. Nature 1936; 138: 32.
[http://dx.doi.org/10.1038/138032a0]
[43]
Gray SJ, Benson JA Jr, Reifenstein RW. Chronic stress and peptic ulcer. I. Effect of corticotropin (ACTH) and cortisone on gastric secretion. J Am Med Assoc 1951; 147(16): 1529-37.
[http://dx.doi.org/10.1001/jama.1951.03670330021007] [PMID: 14873720]
[44]
Sandweiss DJ. Effects of adrenocorticotropic hormone (ACTH) and of cortisone on peptic ulcer. I. Clinical review. Gastroenterology 1954; 27(5): 604-16.
[http://dx.doi.org/10.1016/S0016-5085(19)36102-5] [PMID: 13210598]
[45]
Weusten BLAM, Jacobs JWG, Bijlsma JWJ. Corticosteroid pulse therapy in active rheumatoid arthritis. Semin Arthritis Rheum 1993; 23(3): 183-92.
[http://dx.doi.org/10.1016/S0049-0172(05)80039-3] [PMID: 8122121]
[46]
Robert A, Nezamis JE, Lancaster C, Davis JP, Field SO, Hanchar AJ. Mild irritants prevent gastric necrosis through “adaptive cytoprotection” mediated by prostaglandins. Am J Physiol 1983; 245(1): G113-21.
[PMID: 6869543]
[47]
Brzozowski T, Konturek PC, Konturek SJ, et al. Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves. Eur J Pharmacol 2004; 499(1-2): 201-13.
[http://dx.doi.org/10.1016/j.ejphar.2004.07.072] [PMID: 15363968]
[48]
Pajdo R, Brzozowski T, Konturek PC, et al. Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves. Eur J Pharmacol 2001; 427(3): 263-76.
[http://dx.doi.org/10.1016/S0014-2999(01)01246-8] [PMID: 11567657]
[49]
Takeuchi K. Gastric cytoprotection by prostaglandin E2 and prostacyclin: relationship to EP1 and IP receptors. J Physiol Pharmacol 2014; 65(1): 3-14.
[PMID: 24622825]
[50]
Magierowski M, Jasnos K, Kwiecien S, et al. Endogenous prostaglandins and afferent sensory nerves in gastroprotective effect of hydrogen sulfide against stress-induced gastric lesions. PLoS One 2015; 10(3): e0118972
[http://dx.doi.org/10.1371/journal.pone.0118972] [PMID: 25774496]
[51]
Brzozowski T, Konturek PC, Pajdo R, et al. Physiological mediators in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced impairment of gastric mucosal defense and adaptation. Focus on nitric oxide and lipoxins. J Physiol Pharmacol 2008; 59(Suppl. 2): 89-102.
[PMID: 18812631]
[52]
Wada I, Otaka M, Jin M, et al. Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection. Biochem Biophys Res Commun 2006; 349(2): 611-8.
[http://dx.doi.org/10.1016/j.bbrc.2006.08.088] [PMID: 16945336]
[53]
Brzozowski T, Konturek PC, Konturek SJ, Brzozowska I, Pawlik T. Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol 2005; 56(Suppl. 5): 33-55.
[PMID: 16247188]
[54]
Foschi D, Toti GL, Del Soldato P, Ferrante F, Galeone M, Rovati V. Adaptive cytoprotection: an endoscopic study in man. Am J Gastroenterol 1986; 81(11): 1035-7.
[PMID: 3776949]
[55]
Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979; 77(3): 433-43.
[http://dx.doi.org/10.1016/0016-5085(79)90002-7] [PMID: 456839]
[56]
Mise S, Tonkic A, Pesutic V, et al. The presentation and organization of adaptive cytoprotection in the rat stomach, duodenum, and colon. Dedicated to André Robert the founder of the concept of cytoprotection and adaptive cytoprotection. Med Sci Monit 2006; 12(4): BR146-53.
[PMID: 16572047]
[57]
Kawano Y, Ohta M, Eguchi H, Iwashita Y, Inomata M, Kitano S. Increased oxidative stress may lead to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rat. J Gastroenterol Hepatol 2013; 28(4): 639-44.
[http://dx.doi.org/10.1111/jgh.12101] [PMID: 23278350]
[58]
Wada K, Kamisaki Y, Kitano M, Kishimoto Y, Nakamoto K, Itoh T. A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life Sci 1996; 59(19): PL295-301.
[http://dx.doi.org/10.1016/0024-3205(96)00500-0] [PMID: 8913334]
[59]
Tanaka A, Hatazawa R, Takahira Y, Izumi N, Filaretova L, Takeuchi K. Preconditioning stress prevents cold restraint stress-induced gastric lesions in rats: roles of COX-1, COX-2, and PLA2. Dig Dis Sci 2007; 52(2): 478-87.
[http://dx.doi.org/10.1007/s10620-006-9394-8] [PMID: 17226073]
[60]
Filaretova L, Bagaeva T, Makara GB. Aggravation of nonsteroidal antiinflammatory drug gastropathy by glucocorticoid deficiency or blockade of glucocorticoid receptors in rats. Life Sci 2002; 71(21): 2457-68.
[http://dx.doi.org/10.1016/S0024-3205(02)02078-7] [PMID: 12270751]
[61]
Filaretova L, Tanaka A, Miyazawa T, Kato S, Takeuchi K. Mechanisms by which endogenous glucocorticoid protects against indomethacin-induced gastric injury in rats. Am J Physiol Gastrointest Liver Physiol 2002; 283(5): G1082-9.
[http://dx.doi.org/10.1152/ajpgi.00189.2002] [PMID: 12381521]
[62]
Podvigina TT, Filaretova LP. [The Influence of Glucocorticoids on the Healing Processes in the Gastric Mucosa]. Usp Fiziol Nauk 2016; 47(1): 3-14.
[PMID: 27149820]
[63]
Hawkey CJ. Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 2000; 119(2): 521-35.
[http://dx.doi.org/10.1053/gast.2000.9561] [PMID: 10930388]
[64]
Vitaic S, Stupnisek M, Drmic D, et al. Nonsteroidal anti-inflammatory drugs-induced failure of lower esophageal and pyloric sphincter and counteraction of sphincters failure with stable gatric pentadecapeptide BPC 157 in rats. J Physiol Pharmacol 2017; 68(2): 265-72.
[PMID: 28614776]
[65]
Wallace JL. Eicosanoids in the gastrointestinal tract. Br J Pharmacol 2019; 176(8): 1000-8.
[http://dx.doi.org/10.1111/bph.14178] [PMID: 29485681]
[66]
Filaretova L. Gastroprotective role of glucocorticoids during NSAID-induced gastropathy. Curr Pharm Des 2013; 19(1): 29-33.
[PMID: 22950503]
[67]
Bobryshev P, Bagaeva T, Filaretova L. Gastroprotective action of glucocorticoid hormones in rats with desensitization of capsaicin-sensitive sensory neurons. Inflammopharmacology 2005; 13(1-3): 217-28.
[http://dx.doi.org/10.1163/156856005774423782] [PMID: 16259741]
[68]
Filaretova L, Bobryshev P, Bagaeva T, Podvigina T, Takeuchi K. Compensatory gastroprotective role of glucocorticoid hormones during inhibition of prostaglandin and nitric oxide production and desensitization of capsaicin-sensitive sensory neurons. Inflammopharmacology 2007; 15(4): 146-53.
[http://dx.doi.org/10.1007/s10787-007-1589-x] [PMID: 17701016]
[69]
Lu NZ, Cidlowski JA. Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 2005; 18(3): 331-42.
[http://dx.doi.org/10.1016/j.molcel.2005.03.025] [PMID: 15866175]
[70]
Filaretova L, Maltcev N, Bogdanov A, Levkovich Y. Role of gastric microcirculation in the gastroprotection by glucocorticoids released during water-restraint stress in rats. Chin J Physiol 1999; 42(3): 145-52.
[PMID: 10707888]
[71]
Filaretova L, Podvigina T, Bagaeva T, Makara G. Gastroprotective action of glucocorticoids during the formation and the healing of indomethacin-induced gastric erosions in rats. J Physiol Paris 2001; 95(1-6): 201-8.
[http://dx.doi.org/10.1016/S0928-4257(01)00026-2] [PMID: 11595438]
[72]
Filaretova LP, Podvigina TT, Bagaeva TR, Tanaka A, Takeuchi K. Mechanisms underlying the gastroprotective action of glucocorticoids released in response to ulcerogenic stress factors. Ann N Y Acad Sci 2004; 1018: 288-92.
[http://dx.doi.org/10.1196/annals.1296.034] [PMID: 15240380]
[73]
Filaretova LP, Podvigina TT, Bobryshev PY, Bagaeva TR, Tanaka A, Takeuchi K. Hypothalamic-pituitary-adrenocortical axis: the hidden gold in gastric mucosal homeostasis. Inflammopharmacology 2006; 14(5-6): 207-13.
[http://dx.doi.org/10.1007/s10787-006-1544-2] [PMID: 17093902]
[74]
Podvigina TT, Bagaeva TP, Morozova OIu, Filaretova LP. [A comparative analysis of corticosterone, cortisol and dexametasone effects on gastric erosion in rats]. Ross Fiziol Zh Im I M Sechenova 2012; 98(7): 879-89.
[PMID: 23074836]
[75]
Conn DL. Resolved: Low-dose prednisone is indicated as a standard treatment in patients with rheumatoid arthritis. Arthritis Rheum 2001; 45(5): 462-7.
[http://dx.doi.org/10.1002/1529-0131(200110)45:5<462:AID-ART366>3.0.CO;2-V] [PMID: 11642646]
[76]
Longui CA. Glucocorticoid therapy: minimizing side effects. J Pediatr (Rio J) 2007; 83(5)(Suppl.): S163-77.
[http://dx.doi.org/10.1590/S0021-75572007000700007] [PMID: 18000630]
[77]
Greenwood-Van Meerveld B, Prusator DK, Johnson AC. Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol 2015; 308(11): G885-903.
[http://dx.doi.org/10.1152/ajpgi.00463.2014] [PMID: 25767262]
[78]
Hattay P, Prusator DK, Johnson AC, Greenwood-Van Meerveld B. Stereotaxic Exposure of the Central Nucleus of the Amygdala to Corticosterone Increases Colonic Permeability and Reduces Nerve-Mediated Active Ion Transport in Rats. Front Neurosci 2018; 12: 543.
[http://dx.doi.org/10.3389/fnins.2018.00543] [PMID: 30154689]
[79]
Yarushkina N, Bogdanov A, Filaretova L. Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. Auton Neurosci 2006; 126-127: 100-5.
[http://dx.doi.org/10.1016/j.autneu.2006.02.009] [PMID: 16580889]
[80]
Chalaye P, Goffaux P, Bourgault P, et al. Comparing pain modulation and autonomic responses in fibromyalgia and irritable bowel syndrome patients. Clin J Pain 2012; 28(6): 519-26.
[http://dx.doi.org/10.1097/AJP.0b013e31823ae69e] [PMID: 22673485]
[81]
Chang L, Mayer EA, Johnson T, FitzGerald LZ, Naliboff B. Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia. Pain 2000; 84(2-3): 297-307.
[http://dx.doi.org/10.1016/S0304-3959(99)00215-8] [PMID: 10666535]
[82]
Yarushkina NI, Bagaeva TR, Filaretova LP. Somatic Pain Sensitivity in Rats Exposed to the Harmful Actions of Indomethacin on the Gastrointestinal Tract. Neurosci Behav Physiol 2015; 45: 781-8.
[http://dx.doi.org/10.1007/s11055-015-0144-2]
[83]
Iovino P, Tremolaterra F, Consalvo D, Sabbatini F, Mazzacca G, Ciacci C. Perception of electrocutaneous stimuli in irritable bowel syndrome. Am J Gastroenterol 2006; 101(3): 596-603.
[http://dx.doi.org/10.1111/j.1572-0241.2006.00414.x] [PMID: 16464229]
[84]
Mousa S, Miller CH Jr, Couri D. Corticosteroid modulation and stress-induced analgesia in rats. Neuroendocrinology 1981; 33(5): 317-9.
[http://dx.doi.org/10.1159/000123252] [PMID: 7301053]
[85]
MacLennan AJ, Drugan RC, Hyson RL, Maier SF, Madden J IV, Barchas JD. Corticosterone: a critical factor in an opioid form of stress-induced analgesia. Science 1982; 215(4539): 1530-2.
[http://dx.doi.org/10.1126/science.7063862] [PMID: 7063862]
[86]
Sutton LC, Fleshner M, Mazzeo R, Maier SF, Watkins LR. A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release. Brain Res 1994; 663(1): 19-29.
[http://dx.doi.org/10.1016/0006-8993(94)90458-8] [PMID: 7850467]
[87]
Filaretov AA, Bogdanov AI, Yarushkina NI. Stress-induced analgesia. The role of hormones produced by the hypophyseal-adrenocortical system. Neurosci Behav Physiol 1996; 26(6): 572-8.
[http://dx.doi.org/10.1007/BF02359502] [PMID: 9121636]
[88]
Long CC, Sadler KE, Kolber BJ. Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice. Physiol Behav 2016; 165: 278-85.
[http://dx.doi.org/10.1016/j.physbeh.2016.08.009] [PMID: 27520589]
[89]
Yarushkina NI. The role of hypothalamo-hypophyseal-adrenocortical system hormones in controlling pain sensitivity. Neurosci Behav Physiol 2008; 38(8): 759-66.
[http://dx.doi.org/10.1007/s11055-008-9044-z] [PMID: 18802775]
[90]
Filaretova LP, Podvigina TT, Bagaeva TR, Filaretov AA. [The long-term depression of the function of the hypothalamo-hypophyseal-adrenocortical system in rats]. Fiziol Zh Im I M Sechenova 1995; 81(1): 24-31.
[PMID: 7489010]
[91]
Zatorski H, Salaga M, Zielińska M, et al. High activity of endogenous opioid system protects against gastric damage development in mouse models of gastric mucosal injury. Pharmacol Rep 2019; 71(2): 218-24.
[http://dx.doi.org/10.1016/j.pharep.2018.10.011] [PMID: 30785059]
[92]
Fan Z-R, Ma J, Ma X-L, et al. The efficacy of dexamethasone on pain and recovery after total hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore) 2018; 97(13)e0100
[http://dx.doi.org/10.1097/MD.0000000000010100] [PMID: 29595631]
[93]
Wegener JT, Kraal T, Stevens MF, Hollmann MW, Kerkhoffs GMMJ, Haverkamp D. Low-dose dexamethasone during arthroplasty: What do we know about the risks? EFORT Open Rev 2017; 1(8): 303-9.
[http://dx.doi.org/10.1302/2058-5241.1.000039] [PMID: 28461961]
[94]
De Oliveira GS Jr, Almeida MD, Benzon HT, McCarthy RJ. Perioperative single dose systemic dexamethasone for postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology 2011; 115(3): 575-88.
[http://dx.doi.org/10.1097/ALN.0b013e31822a24c2] [PMID: 21799397]
[95]
Shih A, Jackson KC. Role of corticosteroids in palliative care. Palliative Care Pharmacotherapy 2007; 21: 69-76.
[96]
Polderman JAW, Farhang-Razi V, van Dieren S, et al. Adverse side-effects of dexamethasone in surgical patients - an abridged Cochrane systematic review. Anaesthesia 2019; 74(7): 929-39.
[http://dx.doi.org/10.1111/anae.14610] [PMID: 30821852]
[97]
Aharon MA, Prittie JE, Buriko K. A review of associated controversies surrounding glucocorticoid use in veterinary emergency and critical care. J Vet Emerg Crit Care (San Antonio) 2017; 27(3): 267-77.
[http://dx.doi.org/10.1111/vec.12603] [PMID: 28449321]
[98]
Zhou G, Ma L, Jing J, Jiang H. A meta-analysis of dexamethasone for pain management in patients with total knee arthroplasty. Medicine (Baltimore) 2018; 97(35): e11753
[http://dx.doi.org/10.1097/MD.0000000000011753] [PMID: 30170371]
[99]
Shaqura M, Li X, Al-Khrasani M, et al. Membrane-bound glucocorticoid receptors on distinct nociceptive neurons as potential targets for pain control through rapid non-genomic effects. Neuropharmacology 2016; 111: 1-13.
[http://dx.doi.org/10.1016/j.neuropharm.2016.08.019] [PMID: 27558347]
[100]
Wang S, Lim G, Zeng Q, et al. Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats. J Neurosci 2004; 24(39): 8595-605.
[http://dx.doi.org/10.1523/JNEUROSCI.3058-04.2004] [PMID: 15456833]
[101]
Kang SY, Roh DH, Kim HW, Han HJ, Beitz AJ, Lee JH. Suppression of adrenal gland-derived epinephrine enhances the corticosterone-induced antinociceptive effect in the mouse formalin test. Eur J Pain 2014; 18(5): 617-28.
[http://dx.doi.org/10.1002/j.1532-2149.2013.00410.x] [PMID: 24155262]
[102]
Zell V, Juif P-É, Hanesch U, Poisbeau P, Anton F, Darbon P. Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons. Eur J Neurosci 2015; 41(3): 390-7.
[http://dx.doi.org/10.1111/ejn.12796] [PMID: 25427854]
[103]
Alexander JK, DeVries AC, Kigerl KA, Dahlman JM, Popovich PG. Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation. Brain Behav Immun 2009; 23(6): 851-60.
[http://dx.doi.org/10.1016/j.bbi.2009.04.001] [PMID: 19361551]
[104]
de Kloet ER. Functional profile of the binary brain corticosteroid receptor system: mediating, multitasking, coordinating, integrating. Eur J Pharmacol 2013; 719(1-3): 53-62.
[http://dx.doi.org/10.1016/j.ejphar.2013.04.053] [PMID: 23876452]
[105]
Groeneweg FL, Karst H, de Kloet ER, Joëls M. Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling. Mol Cell Endocrinol 2012; 350(2): 299-309.
[http://dx.doi.org/10.1016/j.mce.2011.06.020] [PMID: 21736918]
[106]
Harris AP, Holmes MC, de Kloet ER, Chapman KE, Seckl JR. Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour. Psychoneuroendocrinology 2013; 38(5): 648-58.
[http://dx.doi.org/10.1016/j.psyneuen.2012.08.007] [PMID: 22980941]
[107]
de Kloet ER. From receptor balance to rational glucocorticoid therapy. Endocrinology 2014; 155(8): 2754-69.
[http://dx.doi.org/10.1210/en.2014-1048] [PMID: 24828611]
[108]
Johnson AC, Greenwood-Van Meerveld B. Knockdown of steroid receptors in the central nucleus of the amygdala induces heightened pain behaviors in the rat. Neuropharmacology 2015; 93: 116-23.
[http://dx.doi.org/10.1016/j.neuropharm.2015.01.018] [PMID: 25656477]
[109]
Barnes PJ, Adcock I, Spedding M, Vanhoutte PM. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 1993; 14(12): 436-41.
[http://dx.doi.org/10.1016/0165-6147(93)90184-L] [PMID: 7510080]
[110]
Li X, Shaqura M, Mohamed D, et al. Pro- versus Antinociceptive Nongenomic Effects of Neuronal Mineralocorticoid versus Glucocorticoid Receptors during Rat Hind Paw Inflammation. Anesthesiology 2018; 128(4): 796-809.
[http://dx.doi.org/10.1097/ALN.0000000000002087] [PMID: 29356757]

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