Abstract
The phrase molecular target-based drug discovery usually implies an in vitro biochemical assay or battery of assays. One portion of the U.S. National Cancer Institutes drug discovery program, to the contrary, examines molecular targets for cancer therapy in a cell-based format. That approach has a number of sig-nificant limitations, but it has produced databases of significant utility on the activities and structures of tested compounds, as well as on molecular characteristics of the cell types used for testing.
Keywords: cel based profiling, molecular target, cacer genome, NCI cell screen, anticancer agents, protein expression
Current Pharmaceutical Design
Title: Molecular Targets in Cancer Drug Discovery: Cell-Based Profiling
Volume: 6 Issue: 4
Author(s): John N. Weinstein and John K. Buolamwini
Affiliation:
Keywords: cel based profiling, molecular target, cacer genome, NCI cell screen, anticancer agents, protein expression
Abstract: The phrase molecular target-based drug discovery usually implies an in vitro biochemical assay or battery of assays. One portion of the U.S. National Cancer Institutes drug discovery program, to the contrary, examines molecular targets for cancer therapy in a cell-based format. That approach has a number of sig-nificant limitations, but it has produced databases of significant utility on the activities and structures of tested compounds, as well as on molecular characteristics of the cell types used for testing.
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Cite this article as:
Weinstein N. John and Buolamwini K. John, Molecular Targets in Cancer Drug Discovery: Cell-Based Profiling, Current Pharmaceutical Design 2000; 6 (4) . https://dx.doi.org/10.2174/1381612003400894
DOI https://dx.doi.org/10.2174/1381612003400894 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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