Title:Alternative Therapy in the Prevention of Experimental and Clinical Inflammatory Bowel Disease. Impact of Regular Physical Activity, Intestinal Alkaline Phosphatase and Herbal Products
Volume: 26
Issue: 25
Author(s): Jan Bilski, Dagmara Wojcik, Aleksandra Danielak, Agnieszka Mazur-Bialy, Marcin Magierowski, Katherine Tønnesen, Bartosz Brzozowski, Marcin Surmiak, Katarzyna Magierowska, Robert Pajdo, Agata Ptak-Belowska and Tomasz Brzozowski*
Affiliation:
- Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Cracow,Poland
Keywords:
Inflammatory bowel disease, ulcerative colitis, Crohn's disease, obesity, microbiome, intestine alkaline phosphatase, curcumin.
Abstract: Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are multifactorial,
chronic, disabling, and progressive diseases characterised by cyclical nature, alternating between active and quiescent
states. While the aetiology of IBD is not fully understood, this complex of diseases involve a combination
of factors including the genetic predisposition and changes in microbiome as well as environmental risk factors
such as high-fat and low-fibre diets, reduced physical activity, air pollution and exposure to various toxins and
drugs such as antibiotics. The prevalence of both IBD and obesity is increasing in parallel, undoubtedly proving
the existing interactions between these risk factors common to both disorders to unravel poorly recognized cell
signaling and molecular alterations leading to human IBD. Therefore, there is still a significant and unmet need
for supportive and adjunctive therapy for IBD patients directed against the negative consequences of visceral
obesity and bacterial dysbiosis. Among the alternative therapies, a moderate-intensity exercise can benefit the
health and well-being of IBD patients and improve both the healing of human IBD and experimental animal colitis.
Intestinal alkaline phosphatase (IAP) plays an essential role in the maintenance of intestinal homeostasis intestinal
and the mechanism of mucosal defence. The administration of exogenous IAP could be recommended as a
therapeutic strategy for the cure of diseases resulting from the intestinal barrier dysfunction such as IBD. Curcumin,
a natural anti-inflammatory agent, which is capable of stimulating the synthesis of endogenous IAP, represents
another alternative approach in the treatment of IBD. This review was designed to discuss potential “nonpharmacological”
alternative and supplementary therapeutic approaches taking into account epidemiological and
pathophysiological links between obesity and IBD, including changes in the functional parameters of the intestinal
mucosa and alterations in the intestinal microbiome.
