Influence of Biocompatible Coating on Titanium Surface Characteristics

Željka       Petrović; Jozefina       Katić; Ankica       Šarić; Ines       Despotović; Nives       Matijaković; Damir      Kralj; Mirela       Leskovac; Marin       Petković

doi:10.2174/2352094910999200407095723

Abstract

Background: Nowadays investigations in the field of dental implants engineering are focused on bioactivity and osseointegration properties.

Objective: In this study, the oxide-covered titanium was functionalized by vitamin D3 molecules via a simple self-assembly method with the aim to design more corrosion-resistant and at the same time more bioactive surface.

Methods: Surface properties of the D3-coated titanium were examined by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy, and contact angle measurements, while long-term corrosion stability during immersion in an artificial saliva solution was investigated in situ by electrochemical impedance spectroscopy.

Results: Results of all techniques confirmed a successful formation of the vitamin D3 layer on the oxide-covered titanium. Besides very good corrosion resistivity (~5 MΩ cm2), the D3-modified titanium surface induced spontaneous formation of biocompatible bone-like calcium phosphates (CaP).

Conclusion: Observed in vitro CaP-forming ability as a result of D3-modified titanium/artificial saliva interactions could serve as a promising predictor of in vivo bioactivity of implant materials.

Keywords: Titanium, vitamin D3, self-assembly, surface coating, calcium phosphates, corrosion properties.

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[1] 
P.I. Brånemark, R. Adell, U. Breine, B.O. Hansson, J. Lindström,  and A. Ohlsson, "Intra-osseous anchorage of dental prostheses. I. Experimental studies", Scand. J. Plast. Reconstr. Surg., vol. 3, no. 2, pp. 81-100, 1969.
[http://dx.doi.org/10.3109/02844316909036699] [PMID:  4924041] 
[2] 
P.I. Brånemark, R. Adell, T. Albrektsson, U. Lekholm, S. Lundkvist,  and B. Rockler, "Osseointegrated titanium fixtures in the treatment of edentulousness", Biomaterials, vol. 4, no. 1, pp. 25-28, 1983.
[http://dx.doi.org/10.1016/0142-9612(83)90065-0] [PMID:  6838955] 
[3] 
L. Gaviria, J.P. Salcido, T. Guda,  and J.L. Ong, "Current trends in dental implants", J. Korean Assoc. Oral Maxillofac. Surg., vol. 40, no. 2, pp. 50-60, 2014.
[http://dx.doi.org/10.5125/jkaoms.2014.40.2.50] [PMID:  24868501] 
[4] 
R. Smeets, B. Stadlinger, F. Schwarz, B. Beck-Broichsitter, O. Jung, C. Precht, F. Kloss, A. Gröbe, M. Heiland,  and T. Ebker, "Impact of Dental Implant Surface Modifications on Osseoin-tegration", BioMed Res. Int., vol. 2016, p. 16, 2016.
[http://dx.doi.org/10.1155/2016/6285620] 
[5] 
O.M. Al Mugeiren,  and M.A. Baseer, "Dental Implant Bioactive Surface Modifiers: An Update", J. Int. Soc. Prev. Community Dent., vol. 9, no. 1, pp. 1-4, 2019.
[http://dx.doi.org/10.4103/jispcd.JISPCD_303_18] [PMID:  30923686] 
[6] 
A.H. Choi, B. Ben-Nissan, J.P. Matinlinna,  and R.C. Conway, "Current perspectives: calcium phosphate nanocoatings and nanocomposite coatings in dentistry", J. Dent. Res., vol. 92, no. 10, pp. 853-859, 2013.
[http://dx.doi.org/10.1177/0022034513497754] [PMID:  23857642] 
[7] 
T.T. Hägi, L. Enggist, D. Michel, S.J. Ferguson, Y. Liu,  and E.B. Hunziker, "Mechanical insertion properties of calcium-phosphate implant coatings", Clin. Oral Implants Res., vol. 21, no. 11, pp. 1214-1222, 2010.
[http://dx.doi.org/10.1111/j.1600-0501.2010.01916.x] [PMID:  20546252] 
[8] 
C. von Wilmowsky, T. Moest, E. Nkenke, F. Stelzle,  and K.A. Schlegel, "Implants in bone: part I. A current overview about tissue response, surface modifications and future perspectives", Oral Maxillofac. Surg., vol. 18, no. 3, pp. 243-257, 2014.
[http://dx.doi.org/10.1007/s10006-013-0398-1] [PMID:  23435578] 
[9] 
B. Peter, D.P. Pioletti, S. Laïb, B. Bujoli, P. Pilet, P. Janvier, J. Guicheux, P.Y. Zambelli, J.M. Bouler,  and O. Gauthier, "Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration", Bone, vol. 36, no. 1, pp. 52-60, 2005.
[http://dx.doi.org/10.1016/j.bone.2004.10.004] [PMID:  15664002] 
[10] 
J. Abtahi, P. Tengvall,  and P. Aspenberg, "A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants", Bone, vol. 50, no. 5, pp. 1148-1151, 2012.
[http://dx.doi.org/10.1016/j.bone.2012.02.001] [PMID:  22348981] 
[11] 
L. Rojo, B. Gharibi, R. McLister, B.J. Meenan,  and S. Deb, "Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells", Sci. Rep., vol. 6, p. 30548, 2016.
[http://dx.doi.org/10.1038/srep30548] [PMID:  27468811] 
[12] 
D.C. Hansen, "Metal corrosion in the human body: The ultimate bio-corrosion scenario", Electrochem. Soc. Interface, vol. 17, no. 2, pp. 31-34, 2008.
[13] 
N. Eliaz, "Corrosion of metallic biomaterials: A review", Materials (Basel), vol. 12, no. 3, pp. 407-498, 2019.
[http://dx.doi.org/10.3390/ma12030407] [PMID:  30696087] 
[14] 
A. Sicilia, S. Cuesta, G. Coma, I. Arregui, C. Guisasola, E. Ruiz,  and A. Maestro, "Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients", Clin. Oral Implants Res., vol. 19, no. 8, pp. 823-835, 2008.
[http://dx.doi.org/10.1111/j.1600-0501.2008.01544.x] [PMID:  18705814] 
[15] 
M. Syed, R. Chopra,  and V. Sachdev, "Allergic reactions to dental materials-a systematic review", J. Clin. Diagn. Res., vol. 9, no. 10, pp. ZE04-ZE09, 2015.
[http://dx.doi.org/10.7860/JCDR/2015/15640.6589] [PMID:  26557634] 
[16] 
H. Yan, S. Afroz, J. Dalanon, N. Goto, M. Hosoki,  and Y. Matsuka, "Metal allergy patient treated by titanium implant denture: A case report with at least 4-year follow-up", Clin. Case Rep., vol. 6, no. 10, pp. 1972-1977, 2018.
[http://dx.doi.org/10.1002/ccr3.1753] [PMID:  30349710] 
[17] 
G. Trybek, M. Aniko-Włodarczyk,  and J. Kwiatek, "The effect of vitamin D3 on the osteointegration of dental implants article details", Balt J Health Phys Act, vol. 10, pp. 25-33, 2018.
[http://dx.doi.org/10.29359/BJHPA.10.4.02] 
[18] 
G.J. Atkins, P.H. Anderson, D.M. Findlay, K.J. Welldon, C. Vincent, A.C. Zannettino, P.D. O’Loughlin,  and H.A. Morris, "Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 α,25-dihydroxyvitamin D3", Bone, vol. 40, no. 6, pp. 1517-1528, 2007.
[http://dx.doi.org/10.1016/j.bone.2007.02.024] [PMID:  17395559] 
[19] 
J. Katić, A. Šarić, I. Despotović, N. Matijaković, M. Petković,  and Ž. Petrović, "Bioactive Coating on Titanium Dental Implants for Improved Anticorrosion Protection: A Combined Experimental and Theoretical Study", Coatings, vol. 9, p. 612, 2019.
[http://dx.doi.org/10.3390/coatings9100612] 
[20] 
R. Quiñones,  and E.S. Gawalt, "Study of the formation of self-assembled monolayers on nitinol", Langmuir, vol. 23, no. 20, pp. 10123-10130, 2007.
[http://dx.doi.org/10.1021/la701110p] [PMID:  17725369] 
[21] 
A. Boukamp, "A Nonlinear Least Squares Fit procedure for analysis of immittance data of electrochemical systems", Solid State Ion., vol. 20, pp. 31-44, 1986.
[http://dx.doi.org/10.1016/0167-2738(86)90031-7] 
[22] 
A. Mellado-Valero, A.I. Muñoz, V.G. Pina,  and M.F. Sola-Ruiz, "Electrochemical Behaviour and Galvanic Effects of Titanium Implants Coupled to Metallic Suprastructures in Artificial Saliva", Materials (Basel), vol. 11, no. 1, pp. 171-190, 2018.
[http://dx.doi.org/10.3390/ma11010171] [PMID:  29361767] 
[23] 
F.P. Zamborini,  and R.M. Crooks, "Corrosion Passivation of Gold by n-Alkanethiol Self-Assembled Monolayers: Effect of Chain Length and End Group", Langmuir, vol. 14, pp. 3279-3286, 1998.
[http://dx.doi.org/10.1021/la971121o] 
[24] 
R.B. Heimann,  and H.D. Lehmann, Bioceramics Coatings for Medical Implants: Trends and Techniques., 1st ed Wiley-VCH, 2015.
[http://dx.doi.org/10.1002/9783527682294] 
[25] 
K. Lin, Y. Zhou,  and Y. Zhou, "Biomimetic hydroxyapatite porous microspheres with co-substituted essential trace elements: Surfactant-free hydrothermal synthesis, enhanced degradation and drug release", J. Mater. Chem., vol. 21, pp. 16558-16565, 2011.
[http://dx.doi.org/10.1039/c1jm12514a] 
[26] 
L. Berzina-Cimdina,  and N. Borodajenko, Research of Calcium Phosphates Using Fourier Transform In-frared SpectroscopyInfrared Spectroscopy - Materials Sci-ence Engineering and Technology., IntechOpen: Rijeka, 2012.
[27] 
I. Buljan Meić, J. Kontrec,  and D. Domazet Jurašin, "Comparative Study of Calcium Carbonates and Calcium Phosphates Precipitation in Model Systems Mimicking the Inorganic Environment for Biomineralization", Cryst. Growth Des., vol. 17, pp. 1103-1117, 2017.
[http://dx.doi.org/10.1021/acs.cgd.6b01501] 
[28] 
K. Lin, C. Wu,  and J. Chang, "Advances in synthesis of calcium phosphate crystals with controlled size and shape", Acta Biomater., vol. 10, no. 10, pp. 4071-4102, 2014.
[http://dx.doi.org/10.1016/j.actbio.2014.06.017] [PMID:  24954909] 
[29] 
V. Zalite,  and J. Locs, "Characterization of different hydroxyapatite particles for tooth enamel remineralization", Key Eng. Mater., vol. 674, pp. 139-144, 2016.
[http://dx.doi.org/10.4028/www.scientific.net/KEM.674.139] 
[30] 
V. Veldurthy, R. Wei, L. Oz, P. Dhawan, Y.H. Jeon,  and S. Christakos, "Vitamin D, calcium homeostasis and aging", Bone Res., vol. 4, p. 16041, 2016.
[http://dx.doi.org/10.1038/boneres.2016.41] [PMID:  27790378] 
[31] 
C.C. Ferreira, V.P. Ricci, L.L. de Sousa, N.A. Mariano,  and M.G.N. Campos, "Improvement Of Titanium Corrosion Resistance By Coating With Poly-Caprolactone And Poly-Caprolactone/Titanium Dioxide: Potential Application In Heart Valves", Mater. Res., vol. 20, pp. 126-133, 2017.
[http://dx.doi.org/10.1590/1980-5373-mr-2017-0425] 
[32] 
R. Othayoth, P. Mathi, K. Bheemanapally, L. Kakarla,  and M. Botlagunta, "Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue", J. Microencapsul., vol. 32, no. 6, pp. 578-588, 2015.
[http://dx.doi.org/10.3109/02652048.2015.1065921] [PMID:  26218628] 
[33] 
S.V. Dorozhkin, "Amorphous calcium (ortho)phosphates", Acta Biomater., vol. 6, no. 12, pp. 4457-4475, 2010.
[http://dx.doi.org/10.1016/j.actbio.2010.06.031] [PMID:  20609395] 
[34] 
P.H.H. Fischer,  and C.A. Mcdowell, "The Infrared Absorption Spectra Of Urea–Hydrocarbon Adducts", Can. J. Chem., vol. 38, pp. 187-193, 1960.
[http://dx.doi.org/10.1139/v60-025] 
[35] 
S. Wu, "Polar And Nonpolar Interactions In Adhesion", J. Adhes., vol. 5, pp. 39-55, 1973.
[http://dx.doi.org/10.1080/00218467308078437] 
[36] 
M.E. Orazem,  and B. Tribollet, Electrochemical Impedance Spectroscopy., 2nd ed John Wiley & Sons: New York, 2008.
[http://dx.doi.org/10.1002/9780470381588] 
[37] 
G.J. Brug, A.L.G. van den Eeden, M. Sluyters-Rehbach,  and J.H. Sluyters, "The analysis of electrode impedances complicated by the presence of a constant phase element", J. Electroanal. Chem., vol. 176, pp. 275-295, 1984.
[http://dx.doi.org/10.1016/S0022-0728(84)80324-1] 
[38] 
J. Pan, D. Thierry,  and C. Leygraf, "Electrochemical impedance spectroscopy study of the passive oxide film on titanium for implant application", Electrochim. Acta, vol. 41, pp. 1143-1153, 1996.
[http://dx.doi.org/10.1016/0013-4686(95)00465-3] 
[39] 
M. Aziz-Kerrzo, K.G. Conroy, A.M. Fenelon, S.T. Farrell,  and C.B. Breslin, "Electrochemical studies on the stability and corrosion resistance of titanium-based implant materials", Biomaterials, vol. 22, no. 12, pp. 1531-1539, 2001.
[http://dx.doi.org/10.1016/S0142-9612(00)00309-4] [PMID:  11374452] 
[40] 
S. Tamilselvi, R. Murugaraj,  and N. Rajendran, "Electrochemical impedance spectroscopic studies of titanium and its alloys in saline medium", Mater Corros, vol. 58, pp. 113-120, 2007.
[http://dx.doi.org/10.1002/maco.200603979] 
[41] 
T. Kosec, A. Legat, J. Kovač,  and D. Klobčar, "Influence of laser colour marking on the corrosion properties of low alloyed Ti", Coatings, vol. 9, p. 375, 2019.
[http://dx.doi.org/10.3390/coatings9060375] 
[42] 
J.R. Scully, "Polarization resistance method for determination of instantaneous corrosion rates", Corrosion, vol. 56, pp. 199-218, 2000.
[http://dx.doi.org/10.5006/1.3280536] 

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DOI https://dx.doi.org/10.2174/2352094910999200407095723	Print ISSN 2352-0949
Publisher Name Bentham Science Publisher	Online ISSN 2352-0957

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Influence of Biocompatible Coating on Titanium Surface Characteristics

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