Title:Can Triggering Receptors Expressed on Myeloid Cells be used for Diagnosis of Salmonella Typhi Infection?
Volume: 20
Issue: 9
Author(s): Maysaa E.S. Zaki*, Sally Abed, Mohamed Elegezy, Muhammed Diasty, Nashwa Yousef Ebrahim Elkhouly, Ehab M. Fahmy and Nesreen M. Kamel
Affiliation:
- Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura,Egypt
Keywords:
Enteric fever, PCT, sTREM1, CRP, blood culture, ELISA.
Abstract:
Background: There is a need for rapid and accurate diagnostic biomarker for diagnosis of
Salmonella fever.
Aims: The aim of the present study was to assess the importance of procalcitonin (PCT), Soluble Triggering
Receptors expressed on Myeloid Cells 1 (sTREM1) and C- reactive protein (CRP) in the diagnosis
of enteric fever with positive blood culture for S.typhi.
Methods: Blood samples were withdrawn from 200 patients with suspected enteric fever and subjected
for the determination of CRP, PCT and sTREM-1.
Results: The sensitivity and specificity for PCT cut off were 97.7% & 82.5%, for CRP the sensitivity
and specificity were 95.3% and 77% and for s-TREM-1 the sensitivity and specificity were 95.3% &
77%.
Conclusion: S-TREM-1 may be considered as a novel biomarker for the diagnosis of enteric fever
with good sensitivity and specificity.
