Title:Radiolabeled Peptides for SPECT and PET Imaging in the Detection of Breast Cancer: Preclinical and Clinical Perspectives
Volume: 27
Issue: 41
Author(s): Hao Fu, Bulin Du, Zijun Chen and Yesen Li*
Affiliation:
- Department of Nuclear Medicine & Minnan PET Center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen,China
Keywords:
Breast cancer, Radiolabeled Peptides, SPECT Imaging, PET Imaging, heterogeneous cancer, Single-
Photon Emission Tomography (SPECT).
Abstract: Breast cancer is the most common cancer in women worldwide. Due to the heterogeneous
nature of breast cancer, the optimal treatment and expected response for each patient may not necessarily
be universal. Molecular imaging techniques could play an important role in the early detection and
targeted therapy evaluation of breast cancer. This review focuses on the development of peptides labeled
with SPECT and PET radionuclides for breast cancer imaging. We summarized the current status
of radiolabeled peptides for different receptors in breast cancer. The characteristics of radionuclides and
major techniques for peptide labeling are also briefly discussed.