Title:Saint John on Patmos: Revelations of the Role of Antineutrophil Cytoplasmic Antibody (ANCA) in Vasculitis
Volume: 27
Issue: 17
关键词:
抗中性粒细胞胞浆抗体(ANCA)、髓过氧化物酶(MPO)、中性粒细胞、多血管炎、蛋白酶-3 (PR3)、免疫荧光图(p-ANCA)、血管炎、抗中性粒细胞胞浆抗体、胞浆免疫荧光图(c-ANCA)。
摘要: Diagnosis of vasculitis is based on the presence of histologic features and serological testing
for antineutrophil cytoplasmic antibodies (ANCA). In patients with vasculitis, two types of ANCA have
been identified: ANCA directed against the neutrophil serine protease proteinase-3 (PR3) which results
in a cytoplasmic immunofluorescence pattern (c-ANCA) and ANCA directed against the neutrophil enzyme
myeloperoxidase (MPO), which results in a perinuclear immunofluorescence pattern (p-ANCA).
Question is if the presence of ANCA is the consequence of abnormal neutrophil adhesion, activation,
and apoptosis. Or is it, through mechanisms which are not totally clear for the moment, the cause of vasculitis.
In the latter case it has to be postulated that ANCA autoantigens are expressed on the cell surface
of viable, or activated, or early-apoptotic neutrophils.
