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Review Article

The Haywain: Anti-synthetase Antibodies in Patients with Inflammatory Diseases: Targeting Monocytes or Neutrophils?

Author(s): Bob Meek and Ger T. Rijkers *

Volume 27, Issue 17, 2020

Page: [2863 - 2871] Pages: 9

DOI: 10.2174/0929867326666191128141215

Price: $65

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Abstract

Autoantibiodies against aminoacyl-tRNA synthetases are found in patients suffering from a wide range of autoimmune and inflammatory disorders. Recent data indicate that these antibodies are directed against splice-variants of synthetase genes, the so-called catalytic nulls. Latter molecules have cytokine-like functions and are involved in the regulation of the activation of lymphocytes, monocytes and granulocytes. The potential role of anti-synthetase antibodies as a diagnostic tool and a target for therapeutic interventions is discussed.

Keywords: Anti-synthetase, dermatomyositis, polymyositis, interstitial lung disease, aminoacyl-tRNA, inflammatory diseases.

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