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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Polyoxometalates in Biomedicine: Update and Overview

Author(s): Mirjana B. Čolović, Milan Lacković, Jovana Lalatović, Ali S. Mougharbel, Ulrich Kortz* and Danijela Z. Krstić*

Volume 27, Issue 3, 2020

Page: [362 - 379] Pages: 18

DOI: 10.2174/0929867326666190827153532

Price: $65


Background: Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of interest in the fields of catalysis, electronics, magnetic materials and nanotechnology. Moreover, POMs were shown to exhibit biological activities in vitro and in vivo, such as antitumor, antimicrobial, and antidiabetic.

Methods: The literature search for this peer-reviewed article was performed using PubMed and Scopus databases with the help of appropriate keywords.

Results: This review gives a comprehensive overview of recent studies regarding biological activities of polyoxometalates, and their biomedical applications as promising anti-viral, anti-bacterial, anti-tumor, and anti-diabetic agents. Additionally, their putative mechanisms of action and molecular targets are particularly considered.

Conclusion: Although a wide range of biological activities of Polyoxometalates (POMs) has been reported, they are to the best of our knowledge not close to a clinical trial or a final application in the treatment of diabetes or infectious and malignant diseases. Accordingly, further studies should be directed towards determining the mechanism of POM biological actions, which would enable fine-tuning at the molecular level, and consequently efficient action towards biological targets and as low toxicity as possible. Furthermore, biomedical studies should be performed on solutionstable POMs employing physiological conditions and concentrations.

Keywords: Polyoxometalates, antiviral, antibacterial, antitumor, normoglycemic activities, biomedicine.

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