Abstract
This review surveys the literature published on the emerging biological properties of furanodienone. Furanodienone (FDN) (1) is a furanosesquiterpenoid belonging to the class of furanogermacranes. This class of secondary metabolites is usually not widespread as they are present only in Asteraceae, Apiaceae, Myrtaceae, Lauraceae, Zingiberaceae and Burseraceae. It is commonly isolated from several species of Curcuma and Commiphora. This compound was shown to have several interesting activities, e.g. anti-inflammatory, antimicrobial and anticancer activity. Several in vitro and in vivo studies showed that FDN is able to inhibit several proinflammatory enzymes, such as COX and LOX, it decreases NO generation and reduces the production of proinflammatory cytokines. Furthermore, it is able to inhibit cell proliferation in different cancer cell lines, through the induction of apoptosis. Tested against several microorganism, FDN showed an antibacterial activity against Gram (+) and Gram (-) bacteria, an antifungal activity against pathogenic and phytopathogenic fungi, and an antiprotozoal activity against Trypanosoma brucei.
Keywords: Anti-inflammatory, antioxidant, commiphora, curcuma, cytotoxicity.
Current Organic Chemistry
Title:Furanodienone: An Emerging Bioactive Furanosesquiterpenoid
Volume: 21 Issue: 4
Author(s): Federica Messina, Giulia Gigliarelli, Alfie Palmier and Maria C. Marcotullio
Affiliation:
Keywords: Anti-inflammatory, antioxidant, commiphora, curcuma, cytotoxicity.
Abstract: This review surveys the literature published on the emerging biological properties of furanodienone. Furanodienone (FDN) (1) is a furanosesquiterpenoid belonging to the class of furanogermacranes. This class of secondary metabolites is usually not widespread as they are present only in Asteraceae, Apiaceae, Myrtaceae, Lauraceae, Zingiberaceae and Burseraceae. It is commonly isolated from several species of Curcuma and Commiphora. This compound was shown to have several interesting activities, e.g. anti-inflammatory, antimicrobial and anticancer activity. Several in vitro and in vivo studies showed that FDN is able to inhibit several proinflammatory enzymes, such as COX and LOX, it decreases NO generation and reduces the production of proinflammatory cytokines. Furthermore, it is able to inhibit cell proliferation in different cancer cell lines, through the induction of apoptosis. Tested against several microorganism, FDN showed an antibacterial activity against Gram (+) and Gram (-) bacteria, an antifungal activity against pathogenic and phytopathogenic fungi, and an antiprotozoal activity against Trypanosoma brucei.
Export Options
About this article
Cite this article as:
Messina Federica, Gigliarelli Giulia, Palmier Alfie and Marcotullio C. Maria, Furanodienone: An Emerging Bioactive Furanosesquiterpenoid, Current Organic Chemistry 2017; 21 (4) . https://dx.doi.org/10.2174/1385272820666161018130431
DOI https://dx.doi.org/10.2174/1385272820666161018130431 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
Related Journals
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Targeted Drug Delivery Using Tuftsin-bearing Liposomes: Implications in the Treatment of Infectious Diseases and Tumors
Current Drug Targets Single Photon Emission Tomography in the Diagnostic Assessment of Cardiac and Vascular Infectious Diseases
Current Radiopharmaceuticals Adverse Systemic Reactions of Antihistamines: Highlights in Sedating Effects, Cardiotoxicity and Drug Interactions
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Application of Nano-based Drug Loading Systems in the Treatment of Neurological Infections: An Updated Review
Current Pharmaceutical Design Molecular Approach to Targeted Therapy for Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
Current Medicinal Chemistry Chemoinfectomics in Drug Design and Development
Anti-Infective Agents Nanomedicines for Brain Targeting: A Patent Review
Recent Patents on Nanomedicine Are Retinoids a Promise for Alzheimer’s Disease Management?
Current Medicinal Chemistry New Strategies and Patent Therapeutics in EBV-Associated Diseases
Mini-Reviews in Medicinal Chemistry Plant Flavonoids as Reservoirs of Therapeutics against Microbial Virulence Traits: A Comprehensive Review Update
Current Pharmaceutical Design Pharmacotherapy of Sickle Cell Disease in Children
Current Pharmaceutical Design Cancer Metastasis: Characterization and Identification of the Behavior of Metastatic Tumor Cells and the Cell Adhesion Molecules, including Carbohydrates
Current Drug Targets - Cardiovascular & Hematological Disorders Caring for HIV-Infected Patients in the ICU in The Highly Active Antiretroviral Therapy Era
Current HIV Research Nanoformulated Antibiotics: the Next Step for Pathogenic Bacteria Control
Current Medicinal Chemistry Next Generation Sequencing in the Management of Leptomeningeal Metastases of Non-Small Cell Lung Cancer: A Case Report and Literature Review
Recent Patents on Anti-Cancer Drug Discovery Role of Cannabinoids in Various Diseases: A Review
Current Pharmaceutical Biotechnology Oral Tolerance and TGF-β -Producing Cells
Inflammation & Allergy - Drug Targets (Discontinued) Moxifloxacin-induced Hypoglycemia in a Non-diabetic Patient
Current Drug Safety Update on Diagnostic and Treatment of Uncomplicated and Complicated Malaria in Adults and Selected Vulnerable Populations
Infectious Disorders - Drug Targets