Title:Antioxidant, Xanthine Oxidase and Monoamine Oxidase Inhibitory Potential of Coumarins: A Review
Volume: 21
Issue: 4
Author(s): Priyanka Dhiman, Neelam Malik, Anurag Khatkar and Mahesh Kulharia
Affiliation:
Keywords:
Antioxidant, xanthine oxidase, monoamine oxidase, coumarins.
Abstract: Excessive and persistent formation of ROS (reactive oxygen species) is a key factor in the origin of
cancer, cardiac problems, inflammatory diseases, multiple organ dysfunction, aging and neurogenerative diseases.
These ROS are produced from exogenous sources (ionizing radiation, chemicals and contaminants) and endogenous
sources (Enzymes like Xanthine Oxidase and Monoamine Oxidase) which further originate a number of diseases
along with genetic mutation. Due to the persistent side effects of synthetic antioxidants, there is flow towards
naturally driven antioxidants as a large number of dietary supplements possess antioxidant potential. Coumarins
are naturally occurring benzopyrones found in a variety of natural plants and exhibit different pharmacological
properties. Among these activities the antioxidant potential of coumarins has been extensively studied that
has been reviewed in this paper.
