Abstract
Understanding of the mechanisms of transplant and xenotransplant rejection represents one of the most important aspects of both basic and clinical immunology. This review discusses the roles of 1) immune response and 2) the influence of various products of arachidonic acid metabolism on immune response in graft survival. The review also includes an overview of novel therapeutic approaches developed to prevent, or at least delay, graft rejection. New discoveries in basic and clinical immunology have generated new areas of research in pharmacology that may prevent rejection more efficiently, a key issue in modern medicine.
Keywords: Xenotransplant, transplant, graft rejection, immune response, hyperacute transplant rejection, acute transplant rejection, chronic transplant rejection, arachidonic acid metabolism
Current Pharmaceutical Design
Title: New Frontiers in the Therapeutic Management of Transplant Rejection
Volume: 12 Issue: 19
Author(s): Juan B. De Sanctis, Jenny V. Garmendia, Anna Radzioch and Danuta Radzioch
Affiliation:
Keywords: Xenotransplant, transplant, graft rejection, immune response, hyperacute transplant rejection, acute transplant rejection, chronic transplant rejection, arachidonic acid metabolism
Abstract: Understanding of the mechanisms of transplant and xenotransplant rejection represents one of the most important aspects of both basic and clinical immunology. This review discusses the roles of 1) immune response and 2) the influence of various products of arachidonic acid metabolism on immune response in graft survival. The review also includes an overview of novel therapeutic approaches developed to prevent, or at least delay, graft rejection. New discoveries in basic and clinical immunology have generated new areas of research in pharmacology that may prevent rejection more efficiently, a key issue in modern medicine.
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Cite this article as:
De Sanctis B. Juan, Garmendia V. Jenny, Radzioch Anna and Radzioch Danuta, New Frontiers in the Therapeutic Management of Transplant Rejection, Current Pharmaceutical Design 2006; 12 (19) . https://dx.doi.org/10.2174/138161206777698990
DOI https://dx.doi.org/10.2174/138161206777698990 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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