Abstract
The renin-angiotensin system (RAS) plays an important role in the homeostasis of the cardiovascular system and in the development of cardiovascular diseases. An abnormal expression or over activation of the local RAS in the heart and vasculature system is one of the most common mechanisms in pathophysiological processes in cardiovascular diseases. This also provides a basis for medical prevention and treatments using chemical approaches. Losartan is a selective nonpeptite antagonist against type 1 angiotensin II receptors (AT1R), and has been applied in medical treatments of a variety of cardiovascular diseases, including essential hypertension. This article reviews direct and indirect cardiovascular effects of losartan on the heart and blood vessels. It summarizes the chemical basis of AT1R for the action site of losartan, focuses on the mechanisms underlying the action of losartan involved in both the heart and vasculature, and reviews the information that may be helpful in the development of new chemical candidates or approaches in the war against cardiovascular diseases.
Keywords: Angiotensin II, heart, losartan, renin-angiotensin system, cardiac remodeling, hypertension
Current Medicinal Chemistry
Title: Cardiovascular Effects of Losartan and Its Relevant Clinical Application
Volume: 16 Issue: 29
Author(s): Feichao Xu, Caiping Mao, Yali Hu, Can Rui, Zhice Xu and Lubo Zhang
Affiliation:
Keywords: Angiotensin II, heart, losartan, renin-angiotensin system, cardiac remodeling, hypertension
Abstract: The renin-angiotensin system (RAS) plays an important role in the homeostasis of the cardiovascular system and in the development of cardiovascular diseases. An abnormal expression or over activation of the local RAS in the heart and vasculature system is one of the most common mechanisms in pathophysiological processes in cardiovascular diseases. This also provides a basis for medical prevention and treatments using chemical approaches. Losartan is a selective nonpeptite antagonist against type 1 angiotensin II receptors (AT1R), and has been applied in medical treatments of a variety of cardiovascular diseases, including essential hypertension. This article reviews direct and indirect cardiovascular effects of losartan on the heart and blood vessels. It summarizes the chemical basis of AT1R for the action site of losartan, focuses on the mechanisms underlying the action of losartan involved in both the heart and vasculature, and reviews the information that may be helpful in the development of new chemical candidates or approaches in the war against cardiovascular diseases.
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Cite this article as:
Xu Feichao, Mao Caiping, Hu Yali, Rui Can, Xu Zhice and Zhang Lubo, Cardiovascular Effects of Losartan and Its Relevant Clinical Application, Current Medicinal Chemistry 2009; 16 (29) . https://dx.doi.org/10.2174/092986709789178046
DOI https://dx.doi.org/10.2174/092986709789178046 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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