Obesity and diabetes impair skeletal muscle metabolism, muscle atrophy,
and contractile function, but the intracellular mechanisms have not been clarified fully.
Increasing evidence suggests that oxidative stress is associated with obesity and
diabetes. Depending on the pathological condition, stress may be affected to a greater
extent. Muscle oxidative stress has been implicated in lipid species composition in type
2 diabetes. This chapter discusses the impact of metabolic disease on the regulation of
lipid species and oxidative stress.
Keywords: Ferroptosis, Lipid species, Oxidative stress, Phospholipid, Skeletal muscle.
