Obesity and diabetes are associated with changes in skeletal muscle quantity
and quality, such as increased ectopic fat, muscle atrophy, and decreased muscle
strength. Skeletal muscle tissue is often affected by metabolic insult because it
remodels cellular size, composition, and function in response to a variety of nutritional
changes. Declining muscle quantity and quality are directly linked to falls and
bedriddenness; understanding the intracellular mechanisms may provide clues for
therapeutic strategies. How metabolic diseases via cellular mechanisms affect muscle
quality and muscle quantity are presented in this chapter.
Keywords: Contraction, Calcium, Diabetes, Fiber type, Motor neuron, Myofibrillar, Obesity, Skeletal muscle, Satellite cell.
