Metabolic diseases such as obesity and diabetes cause disruption of systemic
energy metabolism and are major public health problems, with at least 2 billion people
affected worldwide. Skeletal muscle tissue makes a substantial contribution to
promoting energy efficiency because it remodels cellular size, composition, and
function in response to various nutritional changes. However, metabolic diseases such
as impaired insulin sensitivity can dynamically affect the metabolism of skeletal
muscle. A deeper understanding of myopathology in metabolic disorders may provide
clues for therapeutic strategies to promote skeletal muscle health and improve the
overall quality of life. This chapter presents how metabolic diseases via cellular
mechanisms affect muscle cells and muscle tissue, especially glucose metabolism in
skeletal muscle.
Keywords: Diabetes, Glucose, Obesity, Metabolism, Skeletal muscle.
