The oral cavity reflects the general health of the organism. Signs of a
systemic or syndromic pathology often appear first in the oral cavity rather than
systemically. Systemic diseases that can cause oral manifestations include
endocrinopathies, oncological, cardiovascular, gastrointestinal and neurological
diseases. Oral lesions caused by the treatment of systemic diseases can also be
clinically significant, including those caused by cancer therapies (mucositis) and drugs
that alter salivary flow. Some clinically observable changes in the oral cavity are
disease-specific, while others may simply increase the dentist's level of suspicion. This
short chapter deals with some important systemic pathologies with labial manifestation:
Crohn's disease, Melkersson-Rosenthal syndrome, and chemotherapy-induced
mucositis in cancer patients.
Keywords: Chemotherapy-induced mucositis, Crohn's disease, MelkerssonRosenthal syndrome.
