Over the past two decades, the endoscopic endonasal approach has
significantly expanded the armamentarium of minimally invasive skull base surgery.
Initially developed for the treatment of pituitary adenomas, endoscopic endonasal skull
base surgery (EESBS) has found increasing utility in managing a broad spectrum of
skull base pathologies. Its application extends from the midline, encompassing the
crista galli process to the occipitocervical junction, and laterally to the parasellar areas
and petroclival apex. In recent years, there has been a notable shift from the exclusive
use of endoscopic technology in endonasal pituitary surgery to other neuroendoscopic procedures. This chapter aims to provide the reader with an up-to-date overview of
clinical trials on endoscopic neurosurgery of the skull base, brain, and neuroaxis.
Through a comprehensive review of the state-of-the-art published peer-reviewed
literature, the authors strive to offer a concise summary of the current concepts in this
rapidly advancing field.
Keywords: Brain, Direct visualization, Endoscopic surgery, Neuroaxis, Skull base.
