Neurodegenerative diseases (NDDs) are nervous system disorders that
impact around 30 million people globally. Loss of brain tissue is a hallmark symptom
of NDDs. Amyotrophic lateral sclerosis (ALS), frontotemporal dementia, Parkinson's
disease, Alzheimer's disease, and Huntington's disease are among the NDDs caused by
protein misfolding and inappropriate processing of proteins. In addition,
neurodegeneration has also been linked to oxidative stress, mitochondrial malfunction,
and/or environmental variables strongly correlated with aging. Significant evidence has
been obtained after years of intensive research that shows these factors have a crucial
role in the etiology of prevalent neurodegenerative disorders. Many clues have been
identified regarding neurodegenerative illnesses, but the complexities of these
conditions still make them difficult to understand. This chapter presents a more
straightforward explanation to help individuals better understand NDDs, their etiology,
clinical symptoms, and pathogenesis
Keywords: Ageing, Neurodegenerative diseases, Neurodegenerative disorders, Neurodegeneration, Parkinson’s disease.
