Electrochemical Sensors Based on Indicator Displacement Assays

Owing to the low cost, fast response, easy miniaturization, portable instrumentation, and multiple analyte detection capabilities, electrochemical sensors stand out in the realm of sensing and thus occupy a prominent place in analytical supramolecular chemistry. Over the past several decades, the recognition of biologically and environmentally vital analytes via electrochemical responses (increase or decrease in current density), has attracted much attention from supramolecular chemists. The fabrication of electrochemical sensors through a competitive sensing phenomenon known as indicator displacement assay (IDA) has made them more realistic for target analyte detection. In this chapter, besides discussing various types and techniques of electrochemical sensors, we envisioned discussing diverse IDAbased electrochemical sensors for saccharides, biomarkers, neurotransmitters, and various other analytes. The authors are of the viewpoint that this chapter will meet the needs of the researchers working on the design, fabrication, and application of IDAbased electrochemical sensors.

Keywords: Analyte, Biomarker, Current density, Detection, Electrochemical sensor, Guest, Host, Indicator displacement assay, Indicators, Macrocycle, Recognition, Signal, Signal modulation, Teceptors.