Asthma in children is associated with serious exacerbations that are
modulated by inflammation. The expression of inflammatory cytokines varies
according to the severity of the disease. The transition from the state of exacerbation of
the disease to the state of cure always passes through a relationship between
inflammatory and anti-inflammatory mediators. This study looks at the expression of
IL-38 and NLRP3 inflammasome in severe childhood asthma. NLRP3 inflammasome
is upregulated in severe asthma, contrasting with low levels of IL-38. The
inflammatory pattern of severe asthma in children is characterized by the expression of
IL-17, IL-32, IL-1β, and NLRP3 inflammasome.
Keywords: ELISA, Gene expression, Induced sputum, Immunity, Severe asthma.
