Alzheimer's disease (AD) is the most prevalent form of dementia, and it is
considered a dynamic cognitive decline. Neurofibrillary tangles and nerve cell injury
are important neuropharmacological symptoms for one AD brain. TMP21 is an
important molecule in cellular protein trafficking. TMP21, a protein involved in the
production of neurotic plaques, appears to be dysregulated in AD. As a result, we want
to look into TMP21 dysregulation in Alzheimer's disease, as well as the involvement of
TMP21 in neurotic plaque development and the underlying mechanisms. TMP21's
significance in the creation of neurofibrillary tangles, synaptic disbalance, and nerve
cell death is also explored. It will shed light on the therapeutic potential of regulating
TMP21 as a treatment for AD.
Keywords: Amyloid beta protein, Alzheimer’s disease, Glycogen synthase kinase-3, Tau phosphorylation, TMP21.
