Green Plant Extract-Based Synthesis of Multifunctional Nanoparticles and their Biological Activities

Toxicity of Nanomaterials-Physicochemical Effects

Author(s): Seyed Morteza Naghib* and Hamid Reza Garshasbi *

Pp: 140-167 (28)

DOI: 10.2174/9789815179156123010006

* (Excluding Mailing and Handling)


Nanoparticles (NPs) have the potential to produce deleterious effects on organ, tissue, cellular, subcellular, and protein levels due to their peculiar physicochemical features. Metal NPs are gaining prominence and are being used in a variety of medicinal, consumer, industrial, and military applications. Furthermore, as particle size falls, some metal-based NPs become increasingly poisonous, despite the fact that the same substance is rather innocuous in its bulk form. NPs can also interact with proteins and enzymes within human cells, causing reactive oxygen species to be produced, an inflammatory response to be initiated, and mitochondrial disruption and destruction, ending in apoptosis or necrosis. As a result, deciding whether the advantages of NPs outweigh the hazards presents various challenges.

Keywords: Cellular toxicity, Cytotoxicity, Nanotoxicity, Nanoparticles toxicity.

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