Effective delivery of therapeutic genes to target cells is an essential goal of all
innovative gene therapy endeavours and recombinant vaccine technology. Current use of viral
vectors in achieving this goal has been associated with minimal success and plethora of
unwanted adverse events. As a result, there is an ongoing search for suitable vector platforms
for the delivery of therapeutic genes to target cells. Such agent should be easily manipulated to
accommodate small and large gene inserts and safely deliver Transgenes. This will ensure
effective expression of the gene in target cells. The resulting optimal expression of this gene
may correct defective or deficient gene in individuals receiving gene therapy. This chapter
examines the applications of biopolymers as non-viral gene delivery vectors either alone or as
copolymers.
