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Cancer Genes

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Chromosome 13

Author(s): Aishwarya Raja, Ravi Gor, Saurav Panicker and Satish Ramalingam *

Pp: 1-18 (18)

DOI: 10.2174/9789815136500123020003

* (Excluding Mailing and Handling)

Abstract

Chromosome 13 represents around 4 percent of the total cellular DNA with 115 million base pairs. It is home to various tumor suppressors and oncogenes, such as ADP ribosylation factors like GTPase-11 (ARL11), Retinoblastoma-1 (RB1), Ras-related protein Rap-2a (RAP2A), etc. Most of the somatic mutations in this chromosome lead to cancer development. Further, deletion in this chromosome has been reported to support the cancer of leukemias, lymphomas, etc. In this chapter, we have tried to list cancer-causing genes and their possible oncogenesis in cancer development.

Keywords: Burkitt lymphoma, Cellular differentiation, Cystic nephroma, Epigenetic events, Follicular lymphoma, Hodgkin’s lymphoma, Intercellular communication, Oncogene, Rhabdomyosarcoma, Translocations, Tumor suppressor.

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