Fatty acid biosynthesis is a fundamental process that occurs in all living
organisms and involves multiple reaction steps. Thus, a systematic transfer of the
intermediates between the different catalytic sites is highly required for the efficient
regulation of a pathway as well as for sustaining growth. Multienzyme complex, a
protein complex that comprises a group of interacting enzymes in a specific metabolic
pathway, has been identified to catalyze numerous metabolic pathways, including fatty
acid synthesis. The existence of a lipogenic multienzyme complex that involves protein
interaction between numerous enzymes that took part in fatty acid biosynthesis plays a
key fundamental role in channelling the intermediate substrates. Herein, the growing
evidence for the formation of multienzyme complexes in fatty acid synthesis and the
properties of the complex will be elucidated in this chapter.
Keywords: Protein-protein interaction, Fatty acid biosynthesis, Fatty acid synthase, Lipogenic multienzyme complex.
