It is known that the generation of reactive oxygen species (ROS) caused by
UV irradiation and oxidative reactions accelerate skin aging. Substances that suppress
or eliminate the generation of ROS are called antioxidants. So far, various
mycosporine-like amino acids (MAAs) have been reported to have antioxidative
activities. To prevent damage to the skin caused by ROS and maintain the homeostasis
of the epidermis, skin cells have an endogenous antioxidant system consisting of
enzymatic reactions. Although many points are unclear about the regulatory
mechanisms, it has been suggested that MAAs are involved in the regulation of genes
encoding enzymes that are involved in this system. This chapter provides a
comprehensive overview of the antioxidant activities of MAAs.
Keywords: Antioxidant, Catalase, Glutathione peroxidase, Glutathione reductase, Peroxiredoxin, Oxidation, Reactive oxygen species, Superoxide dismutase, Thioredoxin reductase.
