Personalized
medicine is an evolving field and helps in detecting putative targets for
pharmacological treatment modalities in obesity treatment. Obesity has become a
pandemic and major threat, increasing all causes of mortality and bringing a heavy
cost burden on health budgets. Although bariatric/metabolic surgery justified
its role as the most effective treatment regimen for obesity and related
comorbidities in the long-term, some patients require revisional operations, do
not respond to this treatment option, or experience a relapse of their
co-morbidities. For this reason, detection of possible non-responders and
prediction of patients at high risk for developing cardiovascular or metabolic
adverse events in long-term follow-up is of utmost importance. Therefore, the
individualization of surgical treatment by the use of novel biomarkers has come
into prominence recently. Many biomarkers and gene loci had been identified
related to adiposity, insulin resistance, and oxidative stress. In this brief chapter,
the recent advances and clinical implications of these biomarkers will be elaborated.
Keywords: Bariatric surgery, Biomarkers, Obesity, Oxidative stress, Inflammation, Personalized medicine, Proteomics.
