Progress in the field of enantioselective electrophilic fluorination during
the past eighteen years resulting from fascinating research conducted by twelve
international groups is reviewed. Two complementary strategies for the synthesis
of enantiopure fluorine-containing molecules currently define state-of-the-art in
this area. The use of chiral, non-racemic fluorinating agents is the most general
approach while catalytic methods using either transition-metal catalysts or
organocatalysts apply to specific substrates.
