The purpose of this study is to develop an efficient therapy of combination
antibiotics for the treatment of sexually transmitted infections. The best-preferred
combination of drugs Cefixime trihydrate and Ofloxacin was selected to prepare
bilayer tablets. This combination work against several genito-urinary tract infections.
The Bilayer tablet was prepared in order to tailor the release of the drug to maintain the
peak plasma level of the drug. It contains Cefixime trihydrate as a quick release layer
and Ofloxacin as an extended-release layer. In this tablet, super disintegrant was used
for the rapid release of the Cefixime layer, whereas HPMC was used to prolong the
release of the ofloxacin layer. Drug release study suggests that there is a complete
release of Cefixime within 30 minutes followed by the simultaneous release of
ofloxacin, which was extended up to 24 hours. Current research reveals that Cefixime
trihydrate and ofloxacin bilayer have been successfully developed for use in combating
sexually transmitted infections.
Keywords: Bilayer tablets, Cefixime trihydrate, Ofloxacin, Sexually transmitted
diseases.
