With the increase in the prevalence of chronic microbial infections and
disorders associated with it, the incidence of antibiotic resistance among
microorganisms has continued to rise. Due to this, resistance against conventional
antibiotic therapy is also increasing, which has become a public health concern. It is
necessary to make clinical trials better, improve the idea of research plans, and take
into account the cutting-edge drug safety approaches for the development of antiinfective
drugs. In this regard, biofilm development and quorum sensing associated
virulence approach appears insufficient for the use of traditional antibiotics. The
exploitation of different synthetic and natural compounds for their efficacy in
combating microbial infections associated with QS has been done, but the
compatibility and availability of these compounds limit their applications. Therefore,
for the diagnosis and treatment of infectious diseases, particularly resistant to
antibiotics, nanotechnological interventions offer various biomedical applications.
Nanomaterials exhibit intrinsic anti-infective properties towards the MDR phenomenon
and also can be used as carriers for targeted and site-specific delivery of potential
drugs.
Keywords: Anti-biofilm activity, Bacteriophage, Innate modulators, Microbial
peptide, Microbial biofilms, Nanotechnology systems.
