From the point of view of dosage forms, S-SEDDS represents the solid dose
formulation with self-emulsification features. The S-SEDDS becomes the focal point
when adding liquid or semisolid SE components into powders or nanoparticles through
various solidification strategies, such as adsorption to solid carriers, spray drying, spray
cooling, supercritical liquid-based technique, melt extrusion, nanoparticle technology,
etc. S-SMEDDS offers various benefits, such as diminishing the threat of interaction of
the SMEDDS ingredients with the shell of the capsule. Immediate or controlled-release
formulations can be formulated, relying upon the decision of the powder ingredient to
be incorporated in the formulation; SE granules or pellets diminish the rate of the
gastric emptying time and smooth entry in the gut, which generally leads to less threat
of dosage fluctuations. Various types of S-SMEDDS include SE solid dispersions, SE
tablets, SE enteric-coated dry emulsion, SE beads, SE sustained-release microspheres,
SE nanoparticles, SE mouth dissolving film, SE floating dosage form, positively
charged SMEDDS, self-double-emulsifying drug delivery system, supersaturatable
SMEDDS, and so on. While lecithin-linker SEFs, sponges carrying SMEDDS, herbal
SMEDDS and SE phospholipid suspension are novel S-SMEDDS. Different issues are
related to the solidification strategies, such as the quantity of solidifying ingredients,
the release rate of the drug, degradation of drug amid solidifying procedure, difficulty
in content uniformity, decrease in drug loading limit and the probability of remaining
solvents amid granulation and so on. In this chapter, an attempt has been made to
highlight the various methods for solidifying SMEDDS, their issues and types of Solid-
SMEDDS.
Keywords: Nanoparticles, Self-double-emulsifying drug delivery system
techniques, SE pellets, SE mouth dissolving films, SE phospholipid suspension,
Solid self-microemulsifying drug delivery system.
