• In the US, the Centers for Disease Control and Prevention has estimated
that 2 million patients a year suffer from infections due to drug resistant bacteria and
antimicrobial resistance is predicted to result in 10 million deaths worldwide by 2050.
• Growing antimicrobial resistance combined with a dry antibiotic pipeline has led
clinicians to utilize older antibiotics that can be more toxic and/or ineffective.
• There has been development and regulatory progress made, but this is leading to an
increasing number of antibiotics that will be reaching the market with limited datasets.
Clinicians should understand how to best interpret and incorporate the data into clinical
decision-making.
• Clinicians should understand the various challenges for the decline in antibiotic
development and understand the initiatives that are currently in place to help fix the
issues as well as further potential solutions.
Keywords: Antibiotic, Barriers, Clinical Development, Discovery, Pipeline,
Research, Solutions.
