Fungi are versatile organisms that cause infectious diseases to millions of
people. The disease caused by fungi are rapidly rising in immunocompromised
patients. Commonly available antifungal drugs act on the cell wall and nucleic acid
synthesis and, cell division. However, excessive use of the clinically available common
antifungal drugs has led to the development of multidrug-resistant strains that no longer
respond to treatment. The rapidly emerging multidrug-resistant Candida auris has
caused severe infection and has become a serious burden on public health. Therefore,
the search for new effective compounds especially from endophytes associated with
medicinal plants that have a novel target and mechanism of action against the
multidrug-resistant strains to combat the rapidly emerging infectious diseases caused
by fungi, has become vital.
Keywords: Antifungal compounds, Candida auris, Fungal infections, Multidrugresistant,
Pathogenesis, Symptoms, Treatment.
