Excipients play important functional roles in dosage form manufacturing.
Disintegration and dissolution of dosage form and sometimes the active ingredient is
greatly influenced by the use of excipient(s) like diluents and superdisintegrants in the
formulation. With the advent of FDDF technologies, several directly compressible
excipient systems have been introduced by excipient industry to ease fast
disintegrating/dissolving tablet (FDT) manufacturing by the process of direct
compression. These excipient systems have supplied a royalty free, licensee free and a
low cost solution for FDT manufacturing to drug product manufacturers.
Advancements in disintegrants and disintegration enhancers have also helped in
formulating quicker disintegrating dosage forms. Some new excipients have been used
to overcome bitter taste of drugs, improve compressibility of saccharides and as
diluents in formulating FDTs. Some excipients have been modified and provided in
special for their exclusive use in formulating FDTs. This chapter provides an updated
review on some of the excipient/excipient for their potential use formulating FDTs.
Keywords: Diluent, Mannitol, MCC II, Microcrystalline cellulose, Parteck®
ODT, Pharmaburst®, Polymer, Prosolv® ODT, Saccharides, Superdisintegrant,
Taste masking.
