Highly porous nature of freeze dried materials and their ability to retain
shape and volume have motivated pharmaceutical scientists to explore application of
freeze drying in manufacturing fast dissolving/disintegrating tablets (FDTs). The
process of manufacturing lyophilised tablets as FDTs is extensively proprietary and
patented. Zydis®, Lyoc®, QuickSolv® and NanoCrystal® NanomeltTM technologies have
been successful in developing drug products and obtaining regulatory clearances from
drug regulatory agencies for their marketing authorisations. This chapter aims to
discuss formulation, processing and manufacturing aspects of FDTs prepared by freeze
drying and also provides an overview on some of these patented FDT technologies.
Keywords: Disintegration, Dissolution, Formulation, Freeze casting, Freeze
drying, Gels, Granules, Lyoc®, Lyophilisation, Manufacturing, Matrix,
NanoCrystal®, NanomeltTM, Nanoparticles, Patent, Proprietary, QuickSolv®,
Tablet, Wafer, Zydis®.
