Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects

Neng-Zhong      Xie; Xian-Rui      Chen; Qing-Yan      Wang; Dong      Chen; Qi-Shi      Du; Guo-Ping      Zhou; Ri-Bo      Huang

doi:10.2174/1568026617666170504101646

Abstract

(2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. In addition, it is particularly important to provide chiral groups in drugs. In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the development of microbial cell factories for (2R,3R)-2,3-butanediol production. This article reviews recent advances and challenges in microbial routes to (2R,3R)-2,3- butanediol production, and highlights the metabolic engineering and synthetic biological approaches used to improve titers, yields, productivities, and optical purities. Finally, a systematic and integrative strategy for developing high-performance microbial cell factories is proposed.

Keywords: (2R, 3R)-2, 3-Butanediol, Microbial cell factory, Rational design, Metabolic engineering, Synthetic biology, Systematic and Integrative strategy.

« Previous Next »

Graphical Abstract

Rights & Permissions Print Cite

Current Topics in Medicinal Chemistry

Title:Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects

Volume: 17 Issue: 21

Author(s): Neng-Zhong Xie*, Xian-Rui Chen, Qing-Yan Wang, Dong Chen, Qi-Shi Du, Guo-Ping Zhou*Ri-Bo Huang*

Affiliation:

National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, 530007, Guangxi,China

National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi,China

National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, 530007, Guangxi,China

Keywords: (2R, 3R)-2, 3-Butanediol, Microbial cell factory, Rational design, Metabolic engineering, Synthetic biology, Systematic and Integrative strategy.

Abstract: (2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. In addition, it is particularly important to provide chiral groups in drugs. In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the development of microbial cell factories for (2R,3R)-2,3-butanediol production. This article reviews recent advances and challenges in microbial routes to (2R,3R)-2,3- butanediol production, and highlights the metabolic engineering and synthetic biological approaches used to improve titers, yields, productivities, and optical purities. Finally, a systematic and integrative strategy for developing high-performance microbial cell factories is proposed.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Xie Neng-Zhong*, Chen Xian-Rui, Wang Qing-Yan, Chen Dong, Du Qi-Shi, Zhou Guo-Ping*, Huang Ri-Bo*, Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects, Current Topics in Medicinal Chemistry 2017; 17 (21) . https://dx.doi.org/10.2174/1568026617666170504101646

DOI https://dx.doi.org/10.2174/1568026617666170504101646	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294

About this journal

Call for Papers in Thematic Issues

Submission closes on : 30 April, 2025

AlphaFold in Medicinal Chemistry: Opportunities and Challenges

AlphaFold, a groundbreaking AI tool for protein structure prediction, is revolutionizing drug discovery. Its near-atomic accuracy unlocks new avenues for designing targeted drugs and performing efficient virtual screening. However, AlphaFold's static predictions lack the dynamic nature of proteins, crucial for understanding drug action. This is especially true for multi-domain proteins, ...read more

Guest Editor(s): Dr. Jun Chen

Submission closes on : 27 October, 2024

Artificial intelligence for Natural Products Discovery and Development

Our approach involves using computational methods to predict the potential therapeutic benefits of natural products by considering factors such as drug structure, targets, and interactions. We also employ multitarget analysis to understand the role of drug targets in disease pathways. We advocate for the use of artificial intelligence in predicting ...read more

Guest Editor(s): Dr. Lianxiang Luo

Submission closes on : 24 September, 2024

Chemistry Based on Natural Products for Therapeutic Purposes

The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more

Guest Editor(s): Dr. Parag Jain

Submission closes on : 19 November, 2024

Chronic Kidney Disease

The scope of the special thematic issue includes but not limited to the mechanism of chronic kidney disease (CKD), the treatment of renal fibrosis and early diagnosis of CKD and so on. We also welcome manuscripts from other scientific research area with respect to internal medicine. Cell death has been ...read more

Guest Editor(s): Dr. Li Sun