Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

Title:Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

Volume: 14 Issue: 11

Author(s): Bakr F. Abdel-Wahab*, Abdelbasset A. Farahat, Ghada E. A. Awad and Gamal A. El-Hiti*

Affiliation:

• Department of Chemistry, College of Science and Humanities, Shaqra University, Duwadimi,Saudi Arabia

• Department of Optometry, Cornea Research Chair, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433,Saudi Arabia

Keywords: Drug design, antimicrobial activity, microorganisms, 3-(thiophen-2-yl)pyrazoles, hydrazides, inhibition zone.

Abstract: Background: A series of novel substituted 3-(thiophen-2-yl)pyrazoles was synthesized efficiently and in high yields using simple and convenient procedures starting from 1-phenyl-3- (thiophen-2-yl)-1H-pyrazole-4-carbaldehyde.

Methods: The structures of the newly synthesized products were established and their antimicrobial activities were investigated against some bacteria and fungi.

Results and Conclusion: The products showed excellent antimicrobial activities against the tested microorganism compared to the standard antibacterial and antifungal drugs.

Cite this article as:

Abdel-Wahab F. Bakr *, Farahat A. Abdelbasset , Awad E. A. Ghada and El-Hiti A. Gamal*, Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles, Letters in Drug Design & Discovery 2017; 14 (11) . https://dx.doi.org/10.2174/1570180814666170327162447