Abstract
A series of new biologically potent N-substitutedpyrazoline derivatives have been synthesized by reacting hydrazine hydrate and its derivatives with (2)-1-(4-chlorophenyl)-3-[4-(propan-2- yl)phenyl]prop-2-en-1-one, which in turn prepared by the base catalysed Claisen-Schmidt condensation reaction of 4-(propan-2-yl)benzaldehyde and 4-chloroacetophenone. All the synthesized compounds, 2a-e, 3a-d, 4a,b and 5a-c were screened for their in vitro antibacterial, antioxidant, antiproliferative properties and compounds 3b, 4b were evaluated for in vivo anti-inflammatory activity. The docking studies were carried out for these compounds against α-amylase with TREX1 (PDB:3B60) to predict their putative interactions. Some of the tested compounds showed significant antibacterial, antioxidant, antiproliferative, anti-inflammatory activity and molecular binding.
Keywords: Pyrazolines, antibacterial, antioxidant, antiproliferative, anti-inflammatory activity, molecular docking
Letters in Drug Design & Discovery
Title:Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one
Volume: 14 Issue: 2
Author(s): Vinutha V. Salian, Badiadka Narayana, Balladka K. Sarojini, Enumadisetty S. Sindhupriya, Leelavathi N. Madhu and Shama Rao
Affiliation:
Keywords: Pyrazolines, antibacterial, antioxidant, antiproliferative, anti-inflammatory activity, molecular docking
Abstract: A series of new biologically potent N-substitutedpyrazoline derivatives have been synthesized by reacting hydrazine hydrate and its derivatives with (2)-1-(4-chlorophenyl)-3-[4-(propan-2- yl)phenyl]prop-2-en-1-one, which in turn prepared by the base catalysed Claisen-Schmidt condensation reaction of 4-(propan-2-yl)benzaldehyde and 4-chloroacetophenone. All the synthesized compounds, 2a-e, 3a-d, 4a,b and 5a-c were screened for their in vitro antibacterial, antioxidant, antiproliferative properties and compounds 3b, 4b were evaluated for in vivo anti-inflammatory activity. The docking studies were carried out for these compounds against α-amylase with TREX1 (PDB:3B60) to predict their putative interactions. Some of the tested compounds showed significant antibacterial, antioxidant, antiproliferative, anti-inflammatory activity and molecular binding.
Export Options
About this article
Cite this article as:
Salian V. Vinutha, Narayana Badiadka, Sarojini K. Balladka, Sindhupriya S. Enumadisetty, Madhu N. Leelavathi and Rao Shama, Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one, Letters in Drug Design & Discovery 2017; 14 (2) . https://dx.doi.org/10.2174/1570180813666160519151723
DOI https://dx.doi.org/10.2174/1570180813666160519151723 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Graphical Abstracts
Letters in Drug Design & Discovery Small Molecules as Anti-TNF Drugs
Current Medicinal Chemistry Classification of Aurora B Kinase Inhibitors Using Computational Models
Combinatorial Chemistry & High Throughput Screening The Role of Hydrogen Sulfide and H2S-donors in Myocardial Protection Against Ischemia/Reperfusion Injury
Current Medicinal Chemistry Enhanced Brain Targeting of Tegafur Using Novel Lactyl Cholesterol Liposome as a Carrier
Letters in Drug Design & Discovery SPED-(Styrene-Polyethyleneglycol Diacrylate-9-Decen-1-ol) - A Novel Resin for Solid Phase Peptide Synthesis; Synthesis and Characterization of Biologically Potent Endothelin Classes of Peptides
Combinatorial Chemistry & High Throughput Screening Preconditioning with Chronic Cerebral Hypoperfusion Reduces a Focal Cerebral Ischemic Injury and Increases Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 and Matrix Metalloproteinase-2 Expression
Current Neurovascular Research Recent Advances on Patents in Poly(Ethylene Glycol)-Based Drug Delivery
Recent Patents on Drug Delivery & Formulation Modulation of Potassium Channels as a Therapeutic Approach
Current Pharmaceutical Design Cellular Uptake of Neutral Phosphorodiamidate Morpholino Oligomers
Current Pharmaceutical Biotechnology Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years
Current Medicinal Chemistry Development of a Nasal Donepezil-loaded Microemulsion for the Treatment of Alzheimer’s Disease: in vitro and ex vivo Characterization
CNS & Neurological Disorders - Drug Targets Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways
Letters in Drug Design & Discovery Mitochondrial Functionality and Chemical Compound Action on Sperm Function
Current Medicinal Chemistry Pathophysiology of Idiopathic Atrial Fibrillation - Prognostic and Treatment Implications
Current Pharmaceutical Design Clinical Applications for Cardiovascular Magnetic Resonance Imaging at 3 Tesla
Current Cardiology Reviews Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites
Current Medicinal Chemistry Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation
Current Vascular Pharmacology Immunological Facet and Inception after Post-COVID-19 Vaccination
Infectious Disorders - Drug Targets Neuroprotective Effects of Quercetin: From Chemistry to Medicine
CNS & Neurological Disorders - Drug Targets