Title:Novel Isocyanide-Based Three-Component Synthesis of Substituted 9Hfuro[ 2,3-f]chromene-8,9-Dicarboxylates in Water
Volume: 15
Issue: 5
Author(s): Faramarz Rostami-Charati, Zinatossadat Hossaini and Mohammad A. Khalilzadeh
Affiliation:
Keywords:
1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, chromene, dialkyl acetylenedicarboxylates, isocyanides,
Petasites hybridus, three-component reactions, X-ray diffraction
Abstract: Three-component reaction of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, dialkyl acetylenedicarboxylates
and isocyanides in water was described as efficient and green synthetic procedure for preparation of 9Hfuro[
2,3-f]chromene-8,9-dicarboxylates in excellent yield. In these reactions, 1-(6-hydroxy-2-isopropenyl-1-benzofuranyl)-
1-ethanone was extracted from rhizomes of Petasites hybridus from northern Iran. The structure of this compound was
determined by 1H, 13C-NMR and IR spectroscopy and confirmed by X-ray diffraction analysis. This procedure provides
rapid access to novel and diversely substituted 9H-furo[2,3-f]chromene-8,9-dicarboxylate derivatives....