Abstract
Two hydrolytically activated anthraquinone-diclofenac prodrugs have been designed and synthesized. Both prodrugs show significant binding capability to hydroxyapative (HAP), the major component of bone, and hydrolytically activity in simulation physiological conditions in vitro.
Keywords: Bone-targeting, Anthraquinone, Prodrug, Hydrolytic, Bone affinity, Anti-inflammatory
Letters in Drug Design & Discovery
Title: Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics
Volume: 6 Issue: 5
Author(s): Yanbing Duan, Jia Yu, Haifeng Liu and Min Ji
Affiliation:
Keywords: Bone-targeting, Anthraquinone, Prodrug, Hydrolytic, Bone affinity, Anti-inflammatory
Abstract: Two hydrolytically activated anthraquinone-diclofenac prodrugs have been designed and synthesized. Both prodrugs show significant binding capability to hydroxyapative (HAP), the major component of bone, and hydrolytically activity in simulation physiological conditions in vitro.
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Cite this article as:
Duan Yanbing, Yu Jia, Liu Haifeng and Ji Min, Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics, Letters in Drug Design & Discovery 2009; 6 (5) . https://dx.doi.org/10.2174/1570180810906050393
DOI https://dx.doi.org/10.2174/1570180810906050393 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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