Title: Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction
Volume: 6
Issue: 3
Author(s): Luis S. Astudillo, Margarita Gutierrez C., Hugo Gaete, Vladimir V. Kouznetsov, Carlos M. Melendez, J. Antonio Palenzuela and Gabriel Vallejos G.
Affiliation:
Keywords:
2-Aryl-1,2,3,4-tetrahydroquinolines, microwave-heated three-component Povarov (imino Diels-Alder) reaction, dry media
Abstract: A new series of 2-aryl-1,2,3,4-tetrahydroquinolines has been synthesized in good yields through a BiCl3- catalyzed three-component Povarov reaction (imino Diels-Alder cycloaddition) between anilines, benzaldehydes and Nvinylpyrrolidin- 2-one in MeCN. The same series has been prepared without solvent using microwave radiation, which resulted in better yields, a considerable decrease in reaction times and simplified workup.
