Abstract
A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give tbutyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.
Keywords: Anticancer drug, NCX 4040, design, synthesis, mild conditions, LNCaP cancer cell lines, prostate cancer
Letters in Organic Chemistry
Title: Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions
Volume: 5 Issue: 7
Author(s): Mei Xiao, Hongsong Yang, Suzane M. Klein, Christian M. Muenyi, William L. Stone and Yu L. Jiang
Affiliation:
Keywords: Anticancer drug, NCX 4040, design, synthesis, mild conditions, LNCaP cancer cell lines, prostate cancer
Abstract: A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give tbutyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.
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Cite this article as:
Xiao Mei, Yang Hongsong, Klein M. Suzane, Muenyi M. Christian, Stone L. William and Jiang L. Yu, Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982257
DOI https://dx.doi.org/10.2174/157017808785982257 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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