Title:An Overview of Recent Advances in Hantzsch’s Multicomponent Synthesis of 1,4-
Dihydropyridines: A Class of Prominent Calcium Channel Blockers
Volume: 27
Issue: 2
Author(s): Keshav Kumar Saini, Rupal Rani, Muskan, Neena Khanna, Bhupinder Mehta and Rakesh Kumar*
Affiliation:
- Department of Chemistry, University of Delhi, Delhi, 110007, India
Keywords:
Calcium channel blockers, multicomponent reactions, dihydropyridine, hypertension, one-pot synthesis, hantzsch synthesis.
Abstract: Among all the heterocyclic scaffolds, 1,4-dihydropyridine (1,4-DHPs) is an important
class of nitrogen-containing heterocyclic compounds possessing prominent therapeutic
effects, which play an essential role in pharmaceutical chemistry. Multicomponent reactions
(MCRs) have proven to be an invaluable tool for swiftly synthesizing large and structurally diverse
molecules from simple starting materials. The chemists have discovered a large number
of new MCRs for the synthesis of 1,4-dihydropyridine. The synthesis of 1,4-Dihydropyridine
via multicomponent reaction is an efficient procedure in terms of delivering adequate structural
diversity, which is essential for the process of discovering new 1,4-DHPs compounds and their
therapeutics.1,4-dihydropyridines are well-known L-type calcium channel blockers. This review
aims to study and summarize the recent developments in the multicomponent synthesis of
1,4-dihydropyridines and their fused analogs that act as potent antihypertensive drugs. The findings of this study
will prove to be an invaluable resource for researchers in the areas of heterocyclic chemistry, medicinal chemistry,
and drug design.