Title:Desonide Nanoemulsion Gel for Transdermal Absorption Drug Delivery:
Pharmacodynamic and Safety Evaluation
Volume: 20
Issue: 10
Author(s): Jiaqi Zhang, Yu Yao, Hanbing Liu, Qiuyan Ma, Lanyi Huang, Yuan Chen and Huaqing Lin*
Affiliation:
- Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University,
Guangzhou, 510000, China
Keywords:
Desonide, nanoemulsion gel, pharmacodynamic research, safety evaluation, eczema, potency.
Abstract:
Background: When administered transdermally, desonide is ineffective due to its poor solubility.
As a new transdermal delivery system, nanoemulsion gel has demonstrated significant advantages
for drug delivery over conventional formulations. We have established desonide nanoemulsion
gel (DES NE gel) for better transdermal absorption, but its efficacy and safety still need to be evaluated.
This study aims to provide additional evidence demonstrating the improved pharmacodynamics and
safety of transdermal delivery of Desonide via nanoemulsion gel.
Methods: Pharmacodynamics and safety of Desonide nanoemulsion gel were evaluated using Desonate
® as the reference formulation. To assess the difference in curative effect between DES NE gel and
Desonate® and to ensure safety, atopic dermatitis (AD) models in KM mice were developed using
2,4-dinitrofluorobenzene (DNFB). The degree of ear swelling, ear mass difference, thymus, spleen index,
and HE conventional pathology of mice were used as pharmacodynamic evaluation indexes, and
the irritation was predicted by the New Zealand rabbit epidermal stimulation assay.
Results: Nanoemulsion gels may facilitate transdermal penetration of drugs by influencing the skin
condition. Medium and high doses of DES NE gel significantly ameliorated the inflammation and
swelling of the ear caused by dermatitis/eczema in mice. In addition, compared with DES gel, skin irritation
extent did not increase.
Conclusion: Nanoemulsion gel can be applied to improve the efficacy of drugs with low potency or
poor solubility. DES NE gel provides a higher transdermal potential than other delivery systems. In this
study, it was found that nanoemulsion gel is a promising percutaneous carrier of DES. DES NE-GEL
has a significant curative effect on dermatitis/eczema in a mouse model and is expected to provide a
new, efficient, and low toxic preparation for clinical treatment of dermatitis/eczema through the percutaneous
system.
