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Current Molecular Pharmacology

Volume 12, 4 Issues, 2019
ISSN: 1874-4702 (Online)
ISSN: 1874-4672 (Print)
This journal supports open access

Aims & Scope

Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology.

Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.

Current Molecular Pharmacology

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Volume 12

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Number 2



Review Article

Does the Development of Vaccines Advance Solutions for Tuberculosis?

, 12(2): 83 - 104

Manaf AlMatar*, Essam A. Makky, Husam AlMandeal, Emel Eker, Begüm Kayar, Işıl Var and Fatih Köksal


DOI: 10.2174/1874467212666181126151948


Research Article

MiR-597 Targeting 14-3-3σ Enhances Cellular Invasion and EMT in Nasopharyngeal Carcinoma Cells

, 12(2): 105 - 114

Lisha Xie, Tao Jiang, Ailan Cheng, Ting Zhang, Pin Huang, Pei Li, Gebo Wen, Fanghong Lei, Yun Huang, Xia Tang, Jie Gong, Yunpeng Lin, Jianke Kuai* and Weiguo Huang*


DOI: 10.2174/1874467212666181218113930


Research Article

Mephedrone Impact on Matrix Metalloproteinases Activity - Do they Influence the Memory Processes?

, 12(2): 115 - 121

Anna Boguszewska-Czubara*, Jacek Kurzepa, Grażyna Biała, Katarzyna Kaszubska, Karolina Grot, Piotr Tarkowski, Joanna Kowalczyk, Serena Silvestro, Caterina Faggio and Barbara Budzyńska


DOI: 10.2174/1874467212666190114154307


Research Article



Research Article

Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone

, 12(2): 139 - 146

Vishal J. Patel, Amit A. Joharapurkar*, Samadhan G. Kshirsagar, Brijesh K. Sutariya, Maulik S. Patel, Rajesh H. Bahekar and Mukul R. Jain


DOI: 10.2174/1874467212666190212112402


Research Article

Alterations of RNA Metabolism by Proteomic Analysis of Breast Cancer Cells Exposed to Marycin: A New Optically Active Porphyrin

, 12(2): 147 - 159

Elena Taverna, Maida De Bortoli, Elisa Maffioli, Cristina Corno, Emilio Ciusani, Silvio Trivulzio, Arnaldo Pinelli, Gabriella Tedeschi, Paola Perego and Italia Bongarzone*


DOI: 10.2174/1874467212666190204102112


Research Article

Assessment of Genotoxicity of Levosimendan in Human Cultured Lymphocytes

, 12(2): 160 - 165

Abeer M. Rababa'h*, Omar F. Khabour, Karem H. Alzoubi, Dua'a Al-momani and Mera Ababneh


DOI: 10.2174/1874467212666190306164926


Articles Ahead of Print


In-vitro Pre-Treatment of Cancer Cells with TGF-β1: A Novel Approach of Tail Vein Lung Cancer Metastasis Mouse Model for Anti-Metastatic Studies


Ghulam Jilany Khan*, Li Sun, Muhammad Abbas, Muhammad Naveed, Talha Jamshaid, Mirza Muhammad Faran Ashraf Baig and Shengtao Yuan*


View Abstract View on PubMed





Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage


Keane K.Y. Lai*, Cu Nguyen, Kyung-Soon Lee, Albert Lee, David P. Lin, Jia-Ling Teo and Michael Kahn*


View Abstract View on PubMed


Targeting Chromatin Remodeling for Cancer Therapy


Jasmine Kaur, Abdelkader Daoud and Scott T. Eblen*


View Abstract View on PubMed




Mitochondria-Targeted Drugs


Roman A. Zinovkin* and Andrey A. Zamyatnin*


View Abstract View on PubMed


Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Editor's Choice

Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone

, 2019; 12(2): 139 - 146

Vishal J. Patel, Amit A. Joharapurkar*, Samadhan G. Kshirsagar, Brijesh K. Sutariya, Maulik S. Patel, Rajesh H. Bahekar and Mukul R. Jain


DOI: 10.2174/1874467212666190212112402







Molecular Insights of CREB and MAP-K Phosphorylation by Modafinil in Wake-Related Brain Areas

, 2018; 11(2): 140 - 148

Ramses Jimenez-Moreno, Adrian A. Farret-Ramos, Adriana Valle-Ayala, Niurka Trujillo-Paredes and Eric Murillo-Rodriguez*


DOI: 10.2174/1874467209666161214152006



The Non-Genomic Effects of the PPARβγ Agonist GW0742 on Streptozotocin Treated Rat Aorta

, 2018; 11(2): 149 - 154

Noelia Perez-Diaz, Igor Pushkarsky, Nadia Oweis, Lisa A. Lione and Louise S. Mackenzie*


DOI: 10.2174/1874467209666161229124356



The Nephroprotective Effect of N-Acetyl-L-Cysteine and Atorvastatin against Imipenem induced Nephrotoxicity

, 2018; 11(2): 155 - 161

Abeer M. Rababa`h*, Tamara B. Hijjawi, Karem H. Alzoubi, Saddam Al Demour and Mera A. Ababneh


DOI: 10.2174/1874467210666170731115928



Characterization of Imatinib Resistant CML Leukemic Stem/Initiating Cells and Their Sensitivity to CBP/Catenin Antagonists

, 2018; 11(2): 113 - 121

Yi Zhao, Kaijin Wu, Yongfeng Wu, Elizabeth Melendez, Goar Smbatyan, David Massiello and Michael Kahn*


DOI: 10.2174/1874467210666170919155739




Open Access Articles

Anticancer Mechanism of Lobaplatin as Monotherapy and in Combination with Paclitaxel in Human Gastric Cancer

, 2018; 11(4): 316 - 325

Suhang Hua, Xiangyu Kong, Binbin Chen, Wenxin Zhuang, Qian Sun, Wei Yang, Wenzhi Liu* and Yongxing Zhang*





Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures

, 2017; 10(4): 334 - 344

Andrew S. Dore, Andrea Bortolato, Kaspar Hollenstein, Robert K.Y. Cheng, Randy J. Read and Fiona H. Marshall*






Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

, 2015; 8(2): 110 - 122

Jorg Striessnig, Nadine J. Ortner and Alexandra Pinggera






Most Cited Articles

Review Article

Targeting of inflammation for radiation protection and mitigation

, 2018; 11(3): 203-210.

Rasoul Yahyapour, Peyman Amini, Saeed Rezapoor, Abolhasan Rezaeyan, Bagher Farhood, Mohsen Cheki, Hengameh Fallah and Masoud Najafi*


DOI: 10.2174/1874467210666171108165641


Review Article

COX-2 in radiotherapy: A potential target for radioprotection and radiosensitization

, 2018; 11(3): 173-183.

Mohsen Cheki, Rasoul Yahyapour, Bagher Farhood, Abolhassan Rezaeyan, Dheyauldeen Shabeeb, Peyman Amini, Saeed Rezapoor and Masoud Najafi*


DOI: 10.2174/1874467211666180219102520



Review Article

Brain and gut CRF signaling: Biological actions and role in the gastrointestinal tract

, 1 January 2018; 11(1): 51-71.

Yvette Tache*, Muriel Larauche, Pu-Qing Yuan and Mulugeta Million


DOI: 10.2174/1874467210666170224095741


Review Article

Radiation protection and mitigation by natural antioxidants and flavonoids: Implications to radiotherapy and radiation disasters

, 2018; 11(4): 285-304.

Rasoul Yahyapour, Dheyauldeen Shabeeb, Mohsen Cheki, Ahmed Eleojo Musa, Bagher Farhood, Abolhasan Rezaeyan, Peyman Amini, Hengameh Fallah and Masoud Najafi*


DOI: 10.2174/1874467211666180619125653


Review Article

Opioids in the frame of new psychoactive substances network: A complex pharmacological and toxicological issue

, 1 May 2018; 11(2): 97-108.

Ludovic Ventura, Felix Carvalho and Ricardo Jorge Dinis-Oliveira*


DOI: 10.2174/1874467210666170704110146



Research Article

Prooxidant-antioxidant balance and antioxidant properties of Thuja orientalis l: A potential therapeutic approach for diabetes mellitus

, 1 May 2018; 11(2): 109-112.

Daryoush H. Alamdari*, Malihe Aghasizadeh-Sharbaf, Maryam Mohadjerani, Gordon A. Ferns and Amir Avan


DOI: 10.2174/1874467210666170404112211


Review Article

The multi-faceted profile of corticotropin-releasing factor (CRF) family of neuropeptides and of their receptors on the paracrine/local regulation of the inflammatory response

, 1 January 2018; 11(1): 39-50.

Eirini Dermitzaki, Maria Venihaki, Christos Tsatsanis, Achille Gravanis, Pavlina D. Avgoustinaki, George Liapakis and Andrew N. Margioris*


DOI: 10.2174/1874467210666170109164430



Review Article

Mechanisms for radioprotection by melatonin; can it be used as a radiation countermeasure?

, 2019; 12(1): 2-11.

Peyman Amini, Hanifeh Mirtavoos-Mahyari, Elahe Motevaseli, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Mohsen Cheki, Bagher Farhood, Rasoul Yahyapour, Alireza Shirazi, Nouraddin Abdi Goushbolagh and Masoud Najafi*


DOI: 10.2174/1874467211666180802164449


Research Article

L-sulforaphane confers protection against oxidative stress in an in vitro model of age-related macular degeneration

, 2018; 11(3): 237-253.

Nabeela K. Dulull, Daniel A. Dias, Thilini R. Thrimawithana and Faith A. A. Kwa*


DOI: 10.2174/1874467211666180125163009


Review Article

MicroRNAs, cancer and diet: Facts and new exciting perspectives

, 1 May 2018; 11(2): 90-96.

Maria L. Motti, Stefania D`Angelo and Rosaria Meccariello*


DOI: 10.2174/1874467210666171013123733


Research Article

Umbelliferone decreases intracellular pH and sensitizes melanoma cell line A375 to dacarbazin. Comparison with acetazolamide

, 1 May 2018; 11(2): 133-139.

Clementine Puech*, Morgane Chatard, Delphine Felder-Flesch, Nathalie Prevot and Nathalie Perek*


DOI: 10.2174/1874467208666161128152518


Review Article

Kinase targets for mycolic acid biosynthesis in mycobacterium tuberculosis

, 2019; 12(1): 27-49.

Shahinda S.R. Alsayed, Chau C. Beh, Neil R. Foster, Alan D. Payne, Yu Yu and Hendra Gunosewoyo*


DOI: 10.2174/1874467211666181025141114



Most Accessed Articles

Temozolomide: Mechanisms of Action, Repair and Resistance

, 2012; 5(1): 102-114.

Jihong Zhang, Malcolm F.G. Stevens and Tracey D. Bradshaw


DOI: 10.2174/1874467211205010102



MiR-597 Targeting 14-3-3σ Enhances Cellular Invasion and EMT in Nasopharyngeal Carcinoma Cells

, 2019; 12(2): 105-114.

Lisha Xie, Tao Jiang, Ailan Cheng, Ting Zhang, Pin Huang, Pei Li, Gebo Wen, Fanghong Lei, Yun Huang, Xia Tang, Jie Gong, Yunpeng Lin, Jianke Kuai* and Weiguo Huang*


DOI: 10.2174/1874467212666181218113930


Does the Development of Vaccines Advance Solutions for Tuberculosis?

, 2019; 12(2): 83-104.

Manaf AlMatar*, Essam A. Makky, Husam AlMandeal, Emel Eker, Begüm Kayar, Işıl Var and Fatih Köksal


DOI: 10.2174/1874467212666181126151948




Kinase Targets for Mycolic Acid Biosynthesis in Mycobacterium tuberculosis

, 2019; 12(1): 27-49.

Shahinda S.R. Alsayed, Chau C. Beh, Neil R. Foster, Alan D. Payne, Yu Yu and Hendra Gunosewoyo*


DOI: 10.2174/1874467211666181025141114




NADPH Oxidase as a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy

, 2019; 12(1): 50-60.

Keywan Mortezaee, Nasser Hashemi Goradel, Peyman Amini, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Masoud Najafi* and Bagher Farhood*


DOI: 10.2174/1874467211666181010154709



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