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Current Medicinal Chemistry

Volume 26, 42 Issues, 2019
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Ranking and Category

  • 103th of 293 in

    Biochemistry & Molecular Biology

  • 16th of 59 in

    Chemistry, Medicinal

  • 67th of 261 in

    Pharmacology & Pharmacy

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Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth/mini reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Current Medicinal Chemistry

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Volume 26

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Number 5



Biography   Open Access



Editorial   Open Access



Review Article

Redox State in Atrial Fibrillation Pathogenesis and Relevant Therapeutic Approaches

, 26(5): 765 - 779

Alexios S. Antonopoulos*, Athina Goliopoulou, Evangelos Oikonomou, Sotiris Tsalamandris, Georgios-Angelos Papamikroulis, George Lazaros, Eleftherios Tsiamis, George Latsios, Stella Brili, Spyridon Papaioannou, Vasiliki Gennimata and Dimitris Tousoulis


DOI: 10.2174/0929867324666170718130408


Review Article

Biomarkers Associated with Atrial Fibrosis and Remodeling

, 26(5): 780 - 802

Polychronis Dilaveris*, Christos-Konstantinos Antoniou, Panagiota Manolakou, Eleftherios Tsiamis, Konstantinos Gatzoulis and Dimitris Tousoulis


DOI: 10.2174/0929867324666170918122502


Review Article

Biomarkers Associated with Stroke Risk in Atrial Fibrillation

, 26(5): 803 - 823

Adam Ioannou, Nikolaos Papageorgiou*, Debbie Falconer, Onkar Rehal, Emma Sewart, Effimia Zacharia, Konstantinos Toutouzas, Charalambos Vlachopoulos, Gerasimos Siasos, Costas Tsioufis and Dimitris Tousoulis


DOI: 10.2174/0929867324666170718120651


Review Article

Biomarkers Associated with Bleeding Risk in the Setting of Atrial Fibrillation

, 26(5): 824 - 836

Skevos Sideris*, Stefanos Archontakis, George Latsios, George Lazaros, Konstantinos Toutouzas, Eleftherios Tsiamis, Manolis Vavuranakis, Charalampos Vlachopoulos, Konstantinos Gatzoulis, Constantinos Tsioufis and Dimitris Tousoulis


DOI: 10.2174/0929867324666170718124742


Review Article

Inflammatory Biomarkers in Atrial Fibrillation

, 26(5): 837 - 854

Effimia Zacharia, Nikolaos Papageorgiou*, Adam Ioannou, Gerasimos Siasos, Spyridon Papaioannou, Manolis Vavuranakis, George Latsios, Charalampos Vlachopoulos, Konstantinos Toutouzas, Spyridon Deftereos, Rui Providência and Dimitris Tousoulis


DOI: 10.2174/0929867324666170727103357


Review Article

MicroRNAs in Atrial Fibrillation

, 26(5): 855 - 863

Alexandros Briasoulis*, Shikha Sharma, Tesfaye Telila, Sagar Mallikethi-Reddy, Nikolaos Papageorgiou, Evangelos Oikonomou and Dimitris Tousoulis


DOI: 10.2174/0929867324666170920151024


Articles Ahead of Print

Benzimidazole-derived Compounds Designed for Different Targets of Alzheimer’s Disease


Hayrettin Ozan Gulcan*, Açelya Mavideniz, Mustafa Fethi Sahin and Ilkay Erdogan Orhan


View Abstract View on PubMed



Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus


Qingjun Pan*, Yun Guo*, Linjie Guo*, Shuzhen Liao, Chunfei Zhao, Sijie Wang and Hua-feng Liu


View Abstract View on PubMed


Ligand- and Structure-Based Drug Design and Optimization using KNIME


Michael P. Mazanetz*, Charlotte H. F. Goode and Ewa I. Chudyk


View Abstract View on PubMed


Management of Peripheral Neuropathy Induced by Chemotherapy


Maayan Fradkin*, Ron Batash*, Shiran Elmaleh*, Ronen Debi , Pamela Schaffer , Moshe Schaffer and Noam Asna


View Abstract View on PubMed


Recent Advance in Polymer Based Microspheric Systems for Controlled Protein and Peptide Delivery


Yuanyuan Yang, Qiling Chen, Jianyu Lin , Zheng Cai, Guochao Liao*, Kai Wang, Lei Bai , Peng Zhao and Zhiqiang Yu*


View Abstract View on PubMed


DNA Double Strand Breaks Repair Inhibitors: Relevance as Potential New Anticancer Therapeutics


Paulina Kopa , Anna Macieja, Grzegorz Galita, Zbigniew J. Witczak* and Tomasz Poplawski


View Abstract View on PubMed



Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment


Wioletta Rozpedek, Dariusz Pytel, Alicja Nowak-Zdunczyk , Dawid Lewko , Radoslaw Wojtczak , John Alan Diehl* and Ireneusz Majsterek


View Abstract View on PubMed



Abstracts Ahead of Print

Metal Complexes As Promising Agents For Biomedical Applications


Natalia V. Loginova*, Hleb I. Harbatsevich, Nikolai P. Osipovich, Galina A. Ksendzova, Tatsiana V. Koval’chuk and Genrikh I. Polozov


View Abstract


Metabolic reprogramming of cancer by chemicals that target glutaminase isoenzymes


José M. Matés*, José A. Campos-Sandoval, Juan de los Santos-Jiménez, Juan A. Segura, Francisco J. Alonso and Javier Márquez


View Abstract


Targeting n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease


Rodrigo Valenzuela*, Macarena Ortiz, María Catalina Hernández-Rodas, Francisca Echeverría and Luis A. Videla


View Abstract


Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review


Alberto López-de la Rosa, María J González-García, Margarita Calonge* and Amalia Enríquez-de-Salamanca


View Abstract


Targeting Immune Signaling Pathways in Clonal Hematopoiesis


Nessar Ahmad Azrakhsh, Patrycja Mensah-glanowska, Kristoffer Sand and Astrid Olsnes Kittang*


View Abstract




Recent Advances of Chitosan and Its Derivatives in Biomedical Applications


Fei Ding, Jiawei Fu, Chuang Tao, Yanhua Yu, Xianran He, Yangguang Gao and Yongmin Zhang*


View Abstract


Microbiota, Immune System and Autism Spectrum Disorders. An Integrative Model towards Novel Treatment Options


Barbara Carpita, Donatella Marazziti*, Lionella Palego, Gino Giannaccini, Laura Betti and Liliana Dell'Osso


View Abstract


Autoimmune Hepatitis and Stellate Cells; an Insight into the Role of Autophagy


Shahram Golbabapour, Kamran Bagheri-Lankarani, Saeid Ghavami and Bita Geramizadeh*


View Abstract


Open Access Articles

Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension

, 2019; 26(1): 232 - 243

Renata Wawrzyniak, Arlette Yumba Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndler, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz and Michał J. Markuszewski*




Carbohydrate Scaffolds for the Study of the Autism-associated Bacterium, Clostridium bolteae

, 2019; 26: 1 - 7 (E-Pub Ahead of Print)

Brittany Pequegnat and Mario Artur Monteiro*




The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease

, 2018; 25(40): 5578 - 5587

Claus Desler, Meryl S. Lillenes, Tone Tønjum and Lene Juel Rasmussen*




Mycosporine-Like Amino Acids for Skin Photoprotection

, 2018; 25(40): 5512 - 5527

Karl P. Lawrence, Paul F. Long and Antony R. Young*




Common Aspects Influencing the Translocation of SERS to Biomedicine

, 2018; 25(35): 4638 - 4652

Dionysia Tsoutsi, Marcos Sanles-Sobrido, Andreu Cabot and Pilar-Rivera Gil*




Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models

, 2018; 25(35): 4616 - 4637

Matteo Turetta, Fabio Del Ben, Giulia Brisotto, Eva Biscontin, Michela Bulfoni, Daniela Cesselli, Alfonso Colombatti, Giacinto Scoles, Giuseppe Gigli and Loretta L. del Mercato*




Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases

, 2018; 25(27): 3256 - 3271

Shikun Yang, Aimei Li, JianWen Wang, Jun Liu, Yachun Han, Wei Zhang, Yan Chun Li and Hao Zhang*





NGS Technologies as a Turning Point in Rare Disease Research , Diagnosis and Treatment

, 2018; 25(3): 404 - 432

Ana Fernandez-Marmiesse*, Sofia Gouveia and Maria L. Couce *





Lipids as Biomarkers of Cancer and Bacterial Infections

, 2018; 25: 1 - 9 (E-Pub Ahead of Print)

Gerald Larrouy-Maumus *




Immunocontraception: Filamentous Bacteriophage as a Platform for Vaccine Development

, 2017; 24(35): 3907 - 3920

Tatiana I. Samoylova*, Timothy D. Braden, Jennifer A. Spencer and Frank F. Bartol




A Therapeutic Connection between Dietary Phytochemicals and ATP Synthase

, 2017; 24(35): 3894 - 3906

Zulfiqar Ahmad*, Sherif S. Hassan and Sofiya Azim





Major Developments in the Design of Inhibitors along the Kynurenine Pathway

, 2017; 24(23): 2471 - 2495

Kelly R. Jacobs, Gloria Castellano-Gonzalez , Gilles J. Guillemin * and David B. Lovejoy *





Most Cited Articles

Circulating microRNAs as Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives

, 2016; 23(36): 4135-4150.

Hamed Mirzaei, Sara Khataminfar, Saeid Mohammadparast, Soudabeh Shahid Sales, Mina Maftouh, Mohsen Mohammadi, Miganoosh Simonian, Seyed Mohammd Reza Parizadeh, Seyed Mahdi Hassanian and Amir Avan


DOI: 10.2174/0929867323666160818093854





MicroRNAs: Key Players in Microglia and Astrocyte Mediated Inflammation in CNS Pathologies

, 2016; 23(30): 3528-3546.

Aparna Karthikeyan, Radhika Patnala, Shweta P. Jadhav, Ling Eng-Ang and S. Thameem Dheen


DOI: 10.2174/0929867323666160814001040


Adamantane – A Lead Structure for Drugs in Clinical Practice

, 2016; 23(29): 3245-3266.

Katarina Spilovska, Filip Zemek, Jan Korabecny, Eugenie Nepovimova, Ondrej Soukup, Manfred Windisch and Kamil Kuca


DOI: 10.2174/0929867323666160525114026


Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents

, 2016; 23(5): 455-463.

Hamed Mirzaei, Amirhossein Sahebkar, Amir Avan, Mahmoud R. Jaafari, Rasoul Salehi, Hossein Salehi, Hossein Baharvand, Abbas Rezaei, Jamshid Hadjati, John M. Pawelek and Hamid R. Mirzaei


DOI: 10.2174/0929867323666151217122033


Morin: A Promising Natural Drug

, 2016; 23(8): 774-791.

Anna Caselli, Paolo Cirri, Alice Santi and Paolo Paoli


DOI: 10.2174/0929867323666160106150821


Targeting Stim and Orai Proteins as an Alternative Approach in Anticancer Therapy

, 2016; 23(30): 3450-3480.

Francesco Moccia, Estella Zuccolo, Valentina Poletto, Ilaria Turin, Germano Guerra, Paolo Pedrazzoli, Vittorio Rosti, Camillo Porta and Daniela Montagna


DOI: 10.2174/0929867323666160607111220




Most Accessed Articles

Immune Checkpoint Inhibitors and Cardiac Toxicity: An Emerging Issue

, 2018; 25(11): 1327-1339.

Gilda Varricchi*, Giancarlo Marone, Valentina Mercurio, Maria Rosaria Galdiero, Domenico Bonaduce and Carlo G. Tocchetti*


DOI: 10.2174/0929867324666170407125017


Alzheimer's Disease: A Review from the Pathophysiology to Diagnosis, New Perspectives for Pharmacological Treatment

, 2018; 25(26): 3141-3159.

Leide Caroline dos Santos Picanco*, Priscilla F. Ozela, Maiara de Fatima de Brito Brito, Abraao A. Pinheiro, Elias C. Padilha, Francinaldo S. Braga, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos, Joaquín M.C. Rosa and Lorane Izabel da Silva Hage-Melim*


DOI: 10.2174/0929867323666161213101126


Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review

, 2017; 24(27): 3002-3009.

Ron Batash , Noam Asna *, Pamela Schaffer, Nicole Francis and Moshe Schaffer


DOI: 10.2174/0929867324666170516123206


Fc-fusion Proteins in Therapy: An Updated View

, 2017; 24(12): 1228-1237.

Reza Jafari, Naime M. Zolbanin, Houshang Rafatpanah, Jafar Majidi and Tohid Kazemi*


DOI: 10.2174/0929867324666170113112759


Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases

, 2018; 25(32): 3930-3952.

Roberto Russo*, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli and Antonio Calignano


DOI: 10.2174/0929867324666170216113756


Peptide-Drug Conjugate: A Novel Drug Design Approach

, 2017; 24(31): 3373-3396.

Liang Ma, Chao Wang, Zihao He, Biao Cheng, Ling Zheng and Kun Huang*


DOI: 10.2174/0929867324666170404142840


Ketogenic Diet and Other Dietary Intervention Strategies in the Treatment of Cancer

, 2017; 24(12): 1170-1185.

Matteo Vergati, Eriseld Krasniqi, Girolamo D. Monte, Silvia Riondino, Doriana Vallone, Fiorella Guadagni, Patrizia Ferroni* and Mario Roselli


DOI: 10.2174/0929867324666170116122915



The Role of Oxidative Stress Modulators in Breast Cancer

, 2018; 25(33): 4084-4101.

Hande Gurer-Orhan*, Elif Ince, Dilan Konyar, Luciano Saso* and Sibel Suzen


DOI: 10.2174/0929867324666170711114336


Development of Bruton’s Tyrosine Kinase Inhibitors for Rheumatoid Arthritis

, 2018; 25(42): 5847-5859.

Jiahui Lv, Jingde Wu*, Feng He, Ying Qu, Qiuqiong Zhang and Chenggong Yu


DOI: 10.2174/0929867325666180316121951



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